Differential Inhibition of Human Atherosclerotic Plaque–Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies

BACKGROUND: Glycoprotein VI (GPVI) is the essential platelet collagen receptor in atherothrombosis, but its inhibition causes only a mild bleeding tendency. Thus, targeting this receptor has selective antithrombotic potential. OBJECTIVES: This study sought to compare compounds interfering with plate...

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Detalles Bibliográficos
Autores principales: Jamasbi, Janina, Megens, Remco T.A., Bianchini, Mariaelvy, Münch, Götz, Ungerer, Martin, Faussner, Alexander, Sherman, Shachar, Walker, Adam, Goyal, Pankaj, Jung, Stephanie, Brandl, Richard, Weber, Christian, Lorenz, Reinhard, Farndale, Richard, Elia, Natalie, Siess, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Biomedical 2015
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452546/
https://www.ncbi.nlm.nih.gov/pubmed/26046734
http://dx.doi.org/10.1016/j.jacc.2015.03.573

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