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Cumulative Risk, Cumulative Outcome: A 20-Year Longitudinal Study

Cumulative risk (CR) models provide some of the most robust findings in the developmental literature, predicting numerous and varied outcomes. Typically, however, these outcomes are predicted one at a time, across different samples, using concurrent designs, longitudinal designs of short duration, o...

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Autores principales: Atkinson, Leslie, Beitchman, Joseph, Gonzalez, Andrea, Young, Arlene, Wilson, Beth, Escobar, Michael, Chisholm, Vivienne, Brownlie, Elizabeth, Khoury, Jennifer E., Ludmer, Jaclyn, Villani, Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452593/
https://www.ncbi.nlm.nih.gov/pubmed/26030616
http://dx.doi.org/10.1371/journal.pone.0127650
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author Atkinson, Leslie
Beitchman, Joseph
Gonzalez, Andrea
Young, Arlene
Wilson, Beth
Escobar, Michael
Chisholm, Vivienne
Brownlie, Elizabeth
Khoury, Jennifer E.
Ludmer, Jaclyn
Villani, Vanessa
author_facet Atkinson, Leslie
Beitchman, Joseph
Gonzalez, Andrea
Young, Arlene
Wilson, Beth
Escobar, Michael
Chisholm, Vivienne
Brownlie, Elizabeth
Khoury, Jennifer E.
Ludmer, Jaclyn
Villani, Vanessa
author_sort Atkinson, Leslie
collection PubMed
description Cumulative risk (CR) models provide some of the most robust findings in the developmental literature, predicting numerous and varied outcomes. Typically, however, these outcomes are predicted one at a time, across different samples, using concurrent designs, longitudinal designs of short duration, or retrospective designs. We predicted that a single CR index, applied within a single sample, would prospectively predict diverse outcomes, i.e., depression, intelligence, school dropout, arrest, smoking, and physical disease from childhood to adulthood. Further, we predicted that number of risk factors would predict number of adverse outcomes (cumulative outcome; CO). We also predicted that early CR (assessed at age 5/6) explains variance in CO above and beyond that explained by subsequent risk (assessed at ages 12/13 and 19/20). The sample consisted of 284 individuals, 48% of whom were diagnosed with a speech/language disorder. Cumulative risk, assessed at 5/6-, 12/13-, and 19/20-years-old, predicted aforementioned outcomes at age 25/26 in every instance. Furthermore, number of risk factors was positively associated with number of negative outcomes. Finally, early risk accounted for variance beyond that explained by later risk in the prediction of CO. We discuss these findings in terms of five criteria posed by these data, positing a “mediated net of adversity” model, suggesting that CR may increase some central integrative factor, simultaneously augmenting risk across cognitive, quality of life, psychiatric and physical health outcomes.
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spelling pubmed-44525932015-06-09 Cumulative Risk, Cumulative Outcome: A 20-Year Longitudinal Study Atkinson, Leslie Beitchman, Joseph Gonzalez, Andrea Young, Arlene Wilson, Beth Escobar, Michael Chisholm, Vivienne Brownlie, Elizabeth Khoury, Jennifer E. Ludmer, Jaclyn Villani, Vanessa PLoS One Research Article Cumulative risk (CR) models provide some of the most robust findings in the developmental literature, predicting numerous and varied outcomes. Typically, however, these outcomes are predicted one at a time, across different samples, using concurrent designs, longitudinal designs of short duration, or retrospective designs. We predicted that a single CR index, applied within a single sample, would prospectively predict diverse outcomes, i.e., depression, intelligence, school dropout, arrest, smoking, and physical disease from childhood to adulthood. Further, we predicted that number of risk factors would predict number of adverse outcomes (cumulative outcome; CO). We also predicted that early CR (assessed at age 5/6) explains variance in CO above and beyond that explained by subsequent risk (assessed at ages 12/13 and 19/20). The sample consisted of 284 individuals, 48% of whom were diagnosed with a speech/language disorder. Cumulative risk, assessed at 5/6-, 12/13-, and 19/20-years-old, predicted aforementioned outcomes at age 25/26 in every instance. Furthermore, number of risk factors was positively associated with number of negative outcomes. Finally, early risk accounted for variance beyond that explained by later risk in the prediction of CO. We discuss these findings in terms of five criteria posed by these data, positing a “mediated net of adversity” model, suggesting that CR may increase some central integrative factor, simultaneously augmenting risk across cognitive, quality of life, psychiatric and physical health outcomes. Public Library of Science 2015-06-01 /pmc/articles/PMC4452593/ /pubmed/26030616 http://dx.doi.org/10.1371/journal.pone.0127650 Text en © 2015 Atkinson et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Atkinson, Leslie
Beitchman, Joseph
Gonzalez, Andrea
Young, Arlene
Wilson, Beth
Escobar, Michael
Chisholm, Vivienne
Brownlie, Elizabeth
Khoury, Jennifer E.
Ludmer, Jaclyn
Villani, Vanessa
Cumulative Risk, Cumulative Outcome: A 20-Year Longitudinal Study
title Cumulative Risk, Cumulative Outcome: A 20-Year Longitudinal Study
title_full Cumulative Risk, Cumulative Outcome: A 20-Year Longitudinal Study
title_fullStr Cumulative Risk, Cumulative Outcome: A 20-Year Longitudinal Study
title_full_unstemmed Cumulative Risk, Cumulative Outcome: A 20-Year Longitudinal Study
title_short Cumulative Risk, Cumulative Outcome: A 20-Year Longitudinal Study
title_sort cumulative risk, cumulative outcome: a 20-year longitudinal study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452593/
https://www.ncbi.nlm.nih.gov/pubmed/26030616
http://dx.doi.org/10.1371/journal.pone.0127650
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