Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold

Interfering with LPS binding by the co-receptor protein myeloid differentiation factor 2 (MD-2) represents a useful approach for down-regulation of MD-2·TLR4-mediated innate immune signaling, which is implicated in the pathogenesis of a variety of human diseases, including sepsis syndrome. The antag...

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Detalles Bibliográficos
Autores principales: Garate, Jose Antonio, Stöckl, Johannes, del Carmen Fernández-Alonso, María, Artner, Daniel, Haegman, Mira, Oostenbrink, Chris, Jiménez-Barbero, Jesús, Beyaert, Rudi, Heine, Holger, Kosma, Paul, Zamyatina, Alla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452626/
https://www.ncbi.nlm.nih.gov/pubmed/25394365
http://dx.doi.org/10.1177/1753425914550426

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