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Strategy to develop a MAO-A-resistant 5-hydroxy-l-[β-(11)C]tryptophan isotopologue based on deuterium kinetic isotope effects
BACKGROUND: The serotonin precursor 5-hydroxy-l-[β-(11)C]tryptophan ([(11)C]HTP) is in clinical use for localization of neuroendocrine tumors and has been suggested as a proxy marker for pancreatic islet cells. However, degradation by monoamine oxidase-A (MAO-A) reduces retention and the contrast to...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452635/ https://www.ncbi.nlm.nih.gov/pubmed/26116123 http://dx.doi.org/10.1186/s13550-014-0062-2 |