Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F] FDG-PET imaging combined with proteomic approaches

BACKGROUND: Inhibition of mitogen-activated protein kinase (MEK, also known as MAPK2, MAPKK), a key molecule of the Ras/MAPK (mitogen-activated protein kinase) pathway, has shown promising effects on B-raf-mutated and some RAS (rat sarcoma)-activated tumors in clinical trials. The objective of this...

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Detalles Bibliográficos
Autores principales: Tegnebratt, Tetyana, Ruge, Elisabeth, Bader, Sabine, Ishii, Nobuya, Aida, Satoshi, Yoshimura, Yasushi, Ooi, Chia-Huey, Lu, Li, Mitsios, Nicholas, Meresse, Valerie, Mulder, Jan, Pawlak, Michael, Venturi, Miro, Tessier, Jean, Stone-Elander, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452660/
https://www.ncbi.nlm.nih.gov/pubmed/26116108
http://dx.doi.org/10.1186/s13550-014-0034-6

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