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EETs Attenuate Ox-LDL-Induced LTB(4) Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells

Cytochrome P-450 epoxygenase (EPOX)-derived epoxyeicosatrienoic acids (EETs), 5-lipoxygenase (5-LO), and leukotriene B(4) (LTB(4)), the product of 5-LO, all play a pivotal role in the vascular inflammatory process. We have previously shown that EETs can alleviate oxidized low-density lipoprotein (ox...

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Detalles Bibliográficos
Autores principales:	Jiang, Jun-xia, Zhang, Shui-juan, Xiong, Yao-kang, Jia, Yong-liang, Sun, Yan-hong, Lin, Xi-xi, Shen, Hui-juan, Xie, Qiang-min, Yan, Xiao-feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452698/ https://www.ncbi.nlm.nih.gov/pubmed/26035589 http://dx.doi.org/10.1371/journal.pone.0128278

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