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Loss of tau rescues inflammation-mediated neurodegeneration
Neuroinflammation is one of the neuropathological hallmarks of Alzheimer's disease (AD) and related tauopathies. Activated microglia spatially coexist with microtubule-associated protein tau (Mapt or tau)-burdened neurons in the brains of human AD and non-AD tauopathies. Numerous studies have s...
Autores principales: | Maphis, Nicole, Xu, Guixiang, Kokiko-Cochran, Olga N., Cardona, Astrid E., Ransohoff, Richard M., Lamb, Bruce T., Bhaskar, Kiran |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452825/ https://www.ncbi.nlm.nih.gov/pubmed/26089772 http://dx.doi.org/10.3389/fnins.2015.00196 |
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