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Role of Oxidative RNA Damage in Chronic-Degenerative Diseases
Normal cellular metabolism and exposure to ionizing and ultraviolet radiations and exogenous agents produce reactive oxygen species (ROS). Due to their reactivity, they can interact with many critical biomolecules and induce cell damage. The reaction of ROS with free nucleobases, nucleosides, nucleo...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452857/ https://www.ncbi.nlm.nih.gov/pubmed/26078805 http://dx.doi.org/10.1155/2015/358713 |
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author | Fimognari, Carmela |
author_facet | Fimognari, Carmela |
author_sort | Fimognari, Carmela |
collection | PubMed |
description | Normal cellular metabolism and exposure to ionizing and ultraviolet radiations and exogenous agents produce reactive oxygen species (ROS). Due to their reactivity, they can interact with many critical biomolecules and induce cell damage. The reaction of ROS with free nucleobases, nucleosides, nucleotides, or oligonucleotides can generate numerous distinct modifications in nucleic acids. Oxidative damage to DNA has been widely investigated and is strongly implicated in the development of many chronic-degenerative diseases. In contrast, RNA damage is a poorly examined field in biomedical research. In this review, I discuss the importance of RNA as a target of oxidative damage and the role of oxidative damage to RNA in the pathogenesis of some chronic-degenerative diseases, such as neurological disorders, atherosclerosis, and cancer. Furthermore, I review recent evidence suggesting that RNA may be the target for toxic agents and indicating RNA degradation as a powerful tool to treat any pathology in which there is an aberrant expression of mRNA and/or its gene products. |
format | Online Article Text |
id | pubmed-4452857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44528572015-06-15 Role of Oxidative RNA Damage in Chronic-Degenerative Diseases Fimognari, Carmela Oxid Med Cell Longev Review Article Normal cellular metabolism and exposure to ionizing and ultraviolet radiations and exogenous agents produce reactive oxygen species (ROS). Due to their reactivity, they can interact with many critical biomolecules and induce cell damage. The reaction of ROS with free nucleobases, nucleosides, nucleotides, or oligonucleotides can generate numerous distinct modifications in nucleic acids. Oxidative damage to DNA has been widely investigated and is strongly implicated in the development of many chronic-degenerative diseases. In contrast, RNA damage is a poorly examined field in biomedical research. In this review, I discuss the importance of RNA as a target of oxidative damage and the role of oxidative damage to RNA in the pathogenesis of some chronic-degenerative diseases, such as neurological disorders, atherosclerosis, and cancer. Furthermore, I review recent evidence suggesting that RNA may be the target for toxic agents and indicating RNA degradation as a powerful tool to treat any pathology in which there is an aberrant expression of mRNA and/or its gene products. Hindawi Publishing Corporation 2015 2015-05-20 /pmc/articles/PMC4452857/ /pubmed/26078805 http://dx.doi.org/10.1155/2015/358713 Text en Copyright © 2015 Carmela Fimognari. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fimognari, Carmela Role of Oxidative RNA Damage in Chronic-Degenerative Diseases |
title | Role of Oxidative RNA Damage in Chronic-Degenerative Diseases |
title_full | Role of Oxidative RNA Damage in Chronic-Degenerative Diseases |
title_fullStr | Role of Oxidative RNA Damage in Chronic-Degenerative Diseases |
title_full_unstemmed | Role of Oxidative RNA Damage in Chronic-Degenerative Diseases |
title_short | Role of Oxidative RNA Damage in Chronic-Degenerative Diseases |
title_sort | role of oxidative rna damage in chronic-degenerative diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452857/ https://www.ncbi.nlm.nih.gov/pubmed/26078805 http://dx.doi.org/10.1155/2015/358713 |
work_keys_str_mv | AT fimognaricarmela roleofoxidativernadamageinchronicdegenerativediseases |