Asymmetric conformational maturation of HIV-1 reverse transcriptase

HIV-1 reverse transcriptase utilizes a metamorphic polymerase domain that is able to adopt two alternate structures that fulfill catalytic and structural roles, thereby minimizing its coding requirements. This ambiguity introduces folding challenges that are met by a complex maturation process. We h...

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Detalles Bibliográficos
Autores principales: Zheng, Xunhai, Perera, Lalith, Mueller, Geoffrey A, DeRose, Eugene F, London, Robert E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452869/
https://www.ncbi.nlm.nih.gov/pubmed/26037594
http://dx.doi.org/10.7554/eLife.06359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452869/
https://www.ncbi.nlm.nih.gov/pubmed/26037594
http://dx.doi.org/10.7554/eLife.06359

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