Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo

This study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro. The results confirmed that 1 μM naringin performs the best effect and a collection of bone-related genes (RUNX2, COL1A2, OPN, and OCN) had significant...

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Detalles Bibliográficos
Autores principales: Yin, Lihua, Cheng, Wenxiao, Qin, Zishun, Yu, Hongdou, Yu, Zhanhai, Zhong, Mei, Sun, Kemo, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452874/
https://www.ncbi.nlm.nih.gov/pubmed/26078764
http://dx.doi.org/10.1155/2015/758706
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author Yin, Lihua
Cheng, Wenxiao
Qin, Zishun
Yu, Hongdou
Yu, Zhanhai
Zhong, Mei
Sun, Kemo
Zhang, Wei
author_facet Yin, Lihua
Cheng, Wenxiao
Qin, Zishun
Yu, Hongdou
Yu, Zhanhai
Zhong, Mei
Sun, Kemo
Zhang, Wei
author_sort Yin, Lihua
collection PubMed
description This study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro. The results confirmed that 1 μM naringin performs the best effect and a collection of bone-related genes (RUNX2, COL1A2, OPN, and OCN) had significantly higher expression levels compared to the control group. Furthermore, a typical trabecular structure was observed in vivo, surrounded by a large amount of osteoblasts. These results demonstrated that naringin, at a concentration of 1 μM, can efficiently promote the proliferation and differentiation of hPDLSCs both in vitro and in vivo.
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spelling pubmed-44528742015-06-15 Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo Yin, Lihua Cheng, Wenxiao Qin, Zishun Yu, Hongdou Yu, Zhanhai Zhong, Mei Sun, Kemo Zhang, Wei Stem Cells Int Research Article This study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro. The results confirmed that 1 μM naringin performs the best effect and a collection of bone-related genes (RUNX2, COL1A2, OPN, and OCN) had significantly higher expression levels compared to the control group. Furthermore, a typical trabecular structure was observed in vivo, surrounded by a large amount of osteoblasts. These results demonstrated that naringin, at a concentration of 1 μM, can efficiently promote the proliferation and differentiation of hPDLSCs both in vitro and in vivo. Hindawi Publishing Corporation 2015 2015-05-20 /pmc/articles/PMC4452874/ /pubmed/26078764 http://dx.doi.org/10.1155/2015/758706 Text en Copyright © 2015 Lihua Yin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yin, Lihua
Cheng, Wenxiao
Qin, Zishun
Yu, Hongdou
Yu, Zhanhai
Zhong, Mei
Sun, Kemo
Zhang, Wei
Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo
title Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo
title_full Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo
title_fullStr Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo
title_full_unstemmed Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo
title_short Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo
title_sort effects of naringin on proliferation and osteogenic differentiation of human periodontal ligament stem cells in vitro and in vivo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452874/
https://www.ncbi.nlm.nih.gov/pubmed/26078764
http://dx.doi.org/10.1155/2015/758706
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