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Age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation
Objectives: The mechanisms underlying sleep spindles (~11–15 Hz; >0.5 s) help to protect sleep. With age, it becomes increasingly difficult to maintain sleep at a challenging time (e.g., daytime), even after sleep loss. This study compared spindle characteristics during daytime recovery and noctu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452883/ https://www.ncbi.nlm.nih.gov/pubmed/26089788 http://dx.doi.org/10.3389/fnhum.2015.00323 |
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author | Rosinvil, T. Lafortune, M. Sekerovic, Z. Bouchard, M. Dubé, J. Latulipe-Loiselle, A. Martin, N. Lina, J. M. Carrier, J. |
author_facet | Rosinvil, T. Lafortune, M. Sekerovic, Z. Bouchard, M. Dubé, J. Latulipe-Loiselle, A. Martin, N. Lina, J. M. Carrier, J. |
author_sort | Rosinvil, T. |
collection | PubMed |
description | Objectives: The mechanisms underlying sleep spindles (~11–15 Hz; >0.5 s) help to protect sleep. With age, it becomes increasingly difficult to maintain sleep at a challenging time (e.g., daytime), even after sleep loss. This study compared spindle characteristics during daytime recovery and nocturnal sleep in young and middle-aged adults. In addition, we explored whether spindles characteristics in baseline nocturnal sleep were associated with the ability to maintain sleep during daytime recovery periods in both age groups. Methods: Twenty-nine young (15 women and 14 men; 27.3 y ± 5.0) and 31 middle-aged (19 women and 13 men; 51.6 y ± 5.1) healthy subjects participated in a baseline nocturnal sleep and a daytime recovery sleep after 25 hours of sleep deprivation. Spindles were detected on artifact-free Non-rapid eye movement (NREM) sleep epochs. Spindle density (nb/min), amplitude (μV), frequency (Hz), and duration (s) were analyzed on parasagittal (linked-ears) derivations. Results: In young subjects, spindle frequency increased during daytime recovery sleep as compared to baseline nocturnal sleep in all derivations, whereas middle-aged subjects showed spindle frequency enhancement only in the prefrontal derivation. No other significant interaction between age group and sleep condition was observed. Spindle density for all derivations and centro-occipital spindle amplitude decreased whereas prefrontal spindle amplitude increased from baseline to daytime recovery sleep in both age groups. Finally, no significant correlation was found between spindle characteristics during baseline nocturnal sleep and the marked reduction in sleep efficiency during daytime recovery sleep in both young and middle-aged subjects. Conclusion: These results suggest that the interaction between homeostatic and circadian pressure modulates spindle frequency differently in aging. Spindle characteristics do not seem to be linked with the ability to maintain daytime recovery sleep. |
format | Online Article Text |
id | pubmed-4452883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44528832015-06-18 Age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation Rosinvil, T. Lafortune, M. Sekerovic, Z. Bouchard, M. Dubé, J. Latulipe-Loiselle, A. Martin, N. Lina, J. M. Carrier, J. Front Hum Neurosci Neuroscience Objectives: The mechanisms underlying sleep spindles (~11–15 Hz; >0.5 s) help to protect sleep. With age, it becomes increasingly difficult to maintain sleep at a challenging time (e.g., daytime), even after sleep loss. This study compared spindle characteristics during daytime recovery and nocturnal sleep in young and middle-aged adults. In addition, we explored whether spindles characteristics in baseline nocturnal sleep were associated with the ability to maintain sleep during daytime recovery periods in both age groups. Methods: Twenty-nine young (15 women and 14 men; 27.3 y ± 5.0) and 31 middle-aged (19 women and 13 men; 51.6 y ± 5.1) healthy subjects participated in a baseline nocturnal sleep and a daytime recovery sleep after 25 hours of sleep deprivation. Spindles were detected on artifact-free Non-rapid eye movement (NREM) sleep epochs. Spindle density (nb/min), amplitude (μV), frequency (Hz), and duration (s) were analyzed on parasagittal (linked-ears) derivations. Results: In young subjects, spindle frequency increased during daytime recovery sleep as compared to baseline nocturnal sleep in all derivations, whereas middle-aged subjects showed spindle frequency enhancement only in the prefrontal derivation. No other significant interaction between age group and sleep condition was observed. Spindle density for all derivations and centro-occipital spindle amplitude decreased whereas prefrontal spindle amplitude increased from baseline to daytime recovery sleep in both age groups. Finally, no significant correlation was found between spindle characteristics during baseline nocturnal sleep and the marked reduction in sleep efficiency during daytime recovery sleep in both young and middle-aged subjects. Conclusion: These results suggest that the interaction between homeostatic and circadian pressure modulates spindle frequency differently in aging. Spindle characteristics do not seem to be linked with the ability to maintain daytime recovery sleep. Frontiers Media S.A. 2015-06-03 /pmc/articles/PMC4452883/ /pubmed/26089788 http://dx.doi.org/10.3389/fnhum.2015.00323 Text en Copyright © 2015 Rosinvil, Lafortune, Sekerovic, Bouchard, Dubé, Latulipe-Loiselle, Martin, Lina and Carrier. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Rosinvil, T. Lafortune, M. Sekerovic, Z. Bouchard, M. Dubé, J. Latulipe-Loiselle, A. Martin, N. Lina, J. M. Carrier, J. Age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation |
title | Age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation |
title_full | Age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation |
title_fullStr | Age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation |
title_full_unstemmed | Age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation |
title_short | Age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation |
title_sort | age-related changes in sleep spindles characteristics during daytime recovery following a 25-hour sleep deprivation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452883/ https://www.ncbi.nlm.nih.gov/pubmed/26089788 http://dx.doi.org/10.3389/fnhum.2015.00323 |
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