The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle

The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA. DDR signaling pathways are usurped and manipulated by the replication programs of many viruses. Here, we review the p...

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Detalles Bibliográficos
Autores principales: McKinney, Caleb C., Hussmann, Katherine L., McBride, Alison A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452914/
https://www.ncbi.nlm.nih.gov/pubmed/26008695
http://dx.doi.org/10.3390/v7052450
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author McKinney, Caleb C.
Hussmann, Katherine L.
McBride, Alison A.
author_facet McKinney, Caleb C.
Hussmann, Katherine L.
McBride, Alison A.
author_sort McKinney, Caleb C.
collection PubMed
description The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA. DDR signaling pathways are usurped and manipulated by the replication programs of many viruses. Here, we review the papillomavirus (PV) life cycle, highlighting current knowledge of how PVs recruit and engage the DDR to facilitate productive infection.
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spelling pubmed-44529142015-06-04 The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle McKinney, Caleb C. Hussmann, Katherine L. McBride, Alison A. Viruses Review The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA. DDR signaling pathways are usurped and manipulated by the replication programs of many viruses. Here, we review the papillomavirus (PV) life cycle, highlighting current knowledge of how PVs recruit and engage the DDR to facilitate productive infection. MDPI 2015-05-21 /pmc/articles/PMC4452914/ /pubmed/26008695 http://dx.doi.org/10.3390/v7052450 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
McKinney, Caleb C.
Hussmann, Katherine L.
McBride, Alison A.
The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle
title The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle
title_full The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle
title_fullStr The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle
title_full_unstemmed The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle
title_short The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle
title_sort role of the dna damage response throughout the papillomavirus life cycle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452914/
https://www.ncbi.nlm.nih.gov/pubmed/26008695
http://dx.doi.org/10.3390/v7052450
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