Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

Clostridium difficile is a leading cause of antibiotic-associated diarrhea, a significant animal pathogen, and a worldwide public health burden. Most disease-causing strains secrete two exotoxins, TcdA and TcdB, which are considered to be the primary virulence factors. Understanding the role that th...

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Detalles Bibliográficos
Autores principales: Carter, Glen P., Chakravorty, Anjana, Pham Nguyen, Tu Anh, Mileto, Steven, Schreiber, Fernanda, Li, Lucy, Howarth, Pauline, Clare, Simon, Cunningham, Bliss, Sambol, Susan P., Cheknis, Adam, Figueroa, Iris, Johnson, Stuart, Gerding, Dale, Rood, Julian I., Dougan, Gordon, Lawley, Trevor D., Lyras, Dena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453007/
https://www.ncbi.nlm.nih.gov/pubmed/26037121
http://dx.doi.org/10.1128/mBio.00551-15

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