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Celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses by suppressing NF-κB activation in RINm5F beta cells

Upregulation of pro-inflammatory mediators contributes to β-cell destruction and enhanced infiltration of immune cells into pancreatic islets during development of type 1 diabetes mellitus. In this study, we examined the regulatory effects and the mechanisms of action of celastrol against cytotoxici...

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Detalles Bibliográficos
Autores principales:	Ju, Sung Mi, Youn, Gi Soo, Cho, Yoon Shin, Choi, Soo Young, Park, Jinseu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2015
Materias:	Research-Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453024/ https://www.ncbi.nlm.nih.gov/pubmed/25059279 http://dx.doi.org/10.5483/BMBRep.2015.48.3.147

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