Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden

BACKGROUND: Redox stress is a hallmark of the rewired metabolic phenotype of cancer. The underlying dysregulation of reactive oxygen species (ROS) is interconnected with abnormal mitochondrial biogenesis and function. In chronic lymphocytic leukemia (CLL), elevated ROS are implicated in clonal outgr...

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Detalles Bibliográficos
Autores principales: Prinz, Christian, Vasyutina, Elena, Lohmann, Gregor, Schrader, Alexandra, Romanski, Steffen, Hirschhäuser, Christoph, Mayer, Petra, Frias, Corazon, Herling, Carmen D., Hallek, Michael, Schmalz, Hans-Günther, Prokop, Aram, Mougiakakos, Dimitrios, Herling, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453051/
https://www.ncbi.nlm.nih.gov/pubmed/26041471
http://dx.doi.org/10.1186/s12943-015-0378-1

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