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From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria

BACKGROUND: The survival of malaria parasites, under substantial haem-induced oxidative stress in the red blood cells (RBCs) is dependent on the pentose phosphate pathway (PPP). The PPP is the only source of NADPH in the RBC, essential for the production of reduced glutathione (GSH) and for protecti...

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Detalles Bibliográficos
Autores principales:	Yalcin, Ozlem, Oronsky, Bryan, Carvalho, Leonardo J. M., Kuypers, Frans A., Scicinski, Jan, Cabrales, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453052/ https://www.ncbi.nlm.nih.gov/pubmed/26017006 http://dx.doi.org/10.1186/s12936-015-0720-5

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