High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration

INTRODUCTION: Accumulation of insoluble conformationally altered hyperphosphorylated tau occurs as part of the pathogenic process in Alzheimer’s disease (AD) and other tauopathies. In most AD subjects, wild-type (WT) tau aggregates and accumulates in neurofibrillary tangles and dystrophic neurites i...

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Detalles Bibliográficos
Autores principales: Wheeler, Jeanna M., McMillan, Pamela J., Hawk, Michele, Iba, Michiyo, Robinson, Linda, Xu, George J., Dombroski, Beth A., Jeong, Doori, Dichter, Marc A., Juul, Halvor, Loomis, Elaine, Raskind, Murray, Leverenz, James B., Trojanowski, John Q., Lee, Virginia M.Y., Schellenberg, Gerard D., Kraemer, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453289/
https://www.ncbi.nlm.nih.gov/pubmed/26041339
http://dx.doi.org/10.1186/s40478-015-0210-6

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