Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

BACKGROUND: The hypoxia-activated prodrug TH-302 is reduced at its nitroimidazole group and selectively under hypoxic conditions releases the DNA cross-linker bromo-isophosphoramide mustard (Br-IPM). Here, we have explored the effect of Chk1 inhibition on TH-302-mediated pharmacological activities....

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Detalles Bibliográficos
Autores principales: Meng, Fanying, Bhupathi, Deepthi, Sun, Jessica D, Liu, Qian, Ahluwalia, Dharmendra, Wang, Yan, Matteucci, Mark D, Hart, Charles P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453293/
https://www.ncbi.nlm.nih.gov/pubmed/25994202
http://dx.doi.org/10.1186/s12885-015-1387-6

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