New insights into signalling-pathway alterations in rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and young adults. Several recent studies have shed new light on the alterations in signalling pathways and the downstream effects of these pathway alterations in RMS. Many of these effects converge on the fibroblast growth fac...

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Detalles Bibliográficos
Autores principales: Zhu, B, Davie, J K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453439/
https://www.ncbi.nlm.nih.gov/pubmed/25211658
http://dx.doi.org/10.1038/bjc.2014.471
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author Zhu, B
Davie, J K
author_facet Zhu, B
Davie, J K
author_sort Zhu, B
collection PubMed
description Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and young adults. Several recent studies have shed new light on the alterations in signalling pathways and the downstream effects of these pathway alterations in RMS. Many of these effects converge on the fibroblast growth factor and insulin-like growth-factor pathways. These new findings improve the current understanding of RMS, thus offering novel potential therapeutic targets and strategies that may improve the outcome for patients with RMS.
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spelling pubmed-44534392015-06-09 New insights into signalling-pathway alterations in rhabdomyosarcoma Zhu, B Davie, J K Br J Cancer Minireview Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and young adults. Several recent studies have shed new light on the alterations in signalling pathways and the downstream effects of these pathway alterations in RMS. Many of these effects converge on the fibroblast growth factor and insulin-like growth-factor pathways. These new findings improve the current understanding of RMS, thus offering novel potential therapeutic targets and strategies that may improve the outcome for patients with RMS. Nature Publishing Group 2015-01-20 2014-09-11 /pmc/articles/PMC4453439/ /pubmed/25211658 http://dx.doi.org/10.1038/bjc.2014.471 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Minireview
Zhu, B
Davie, J K
New insights into signalling-pathway alterations in rhabdomyosarcoma
title New insights into signalling-pathway alterations in rhabdomyosarcoma
title_full New insights into signalling-pathway alterations in rhabdomyosarcoma
title_fullStr New insights into signalling-pathway alterations in rhabdomyosarcoma
title_full_unstemmed New insights into signalling-pathway alterations in rhabdomyosarcoma
title_short New insights into signalling-pathway alterations in rhabdomyosarcoma
title_sort new insights into signalling-pathway alterations in rhabdomyosarcoma
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453439/
https://www.ncbi.nlm.nih.gov/pubmed/25211658
http://dx.doi.org/10.1038/bjc.2014.471
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