Deficiency of the Novel Exopolyphosphatase Rv1026/PPX2 Leads to Metabolic Downshift and Altered Cell Wall Permeability in Mycobacterium tuberculosis

Mycobacterium tuberculosis can persist for decades in the human host. Stringent response pathways involving inorganic polyphosphate [poly(P)], which is synthesized and hydrolyzed by polyphosphate kinase (PPK) and exopolyphosphatase (PPX), respectively, are believed to play a key regulatory role in b...

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Detalles Bibliográficos
Autores principales: Chuang, Yu-Min, Bandyopadhyay, Nirmalya, Rifat, Dalin, Rubin, Harvey, Bader, Joel S., Karakousis, Petros C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453511/
https://www.ncbi.nlm.nih.gov/pubmed/25784702
http://dx.doi.org/10.1128/mBio.02428-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453511/
https://www.ncbi.nlm.nih.gov/pubmed/25784702
http://dx.doi.org/10.1128/mBio.02428-14

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