Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark

BACKGROUND: Evidence is conflicting regarding statin use and risk of basal cell (BCC) and squamous cell skin cancer (SCC). METHODS: Using Danish nationwide registries, we identified all patients with incident BCC/SCC during 2005–2009 and matched them to population controls. We computed odds ratios (...

Descripción completa

Detalles Bibliográficos
Autores principales: Arnspang, S, Pottegård, A, Friis, S, Clemmensen, O, Andersen, K E, Hallas, J, Gaist, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453598/
https://www.ncbi.nlm.nih.gov/pubmed/25290087
http://dx.doi.org/10.1038/bjc.2014.527
_version_ 1782374481741742080
author Arnspang, S
Pottegård, A
Friis, S
Clemmensen, O
Andersen, K E
Hallas, J
Gaist, D
author_facet Arnspang, S
Pottegård, A
Friis, S
Clemmensen, O
Andersen, K E
Hallas, J
Gaist, D
author_sort Arnspang, S
collection PubMed
description BACKGROUND: Evidence is conflicting regarding statin use and risk of basal cell (BCC) and squamous cell skin cancer (SCC). METHODS: Using Danish nationwide registries, we identified all patients with incident BCC/SCC during 2005–2009 and matched them to population controls. We computed odds ratios (ORs) for BCC and SCC associated with statin use. RESULTS: We identified 38 484 cases of BCC and 3724 cases of SCC. Statin ever use was associated with ORs of 1.09 (CI: 1.06–1.13) for BCC and 1.01 (CI: 0.91–1.11) for SCC. CONCLUSIONS: Statin use was not associated with risk of SCC. Residual confounding plausibly explains the marginally increased risk of BCC.
format Online
Article
Text
id pubmed-4453598
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-44535982016-01-06 Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark Arnspang, S Pottegård, A Friis, S Clemmensen, O Andersen, K E Hallas, J Gaist, D Br J Cancer Short Communication BACKGROUND: Evidence is conflicting regarding statin use and risk of basal cell (BCC) and squamous cell skin cancer (SCC). METHODS: Using Danish nationwide registries, we identified all patients with incident BCC/SCC during 2005–2009 and matched them to population controls. We computed odds ratios (ORs) for BCC and SCC associated with statin use. RESULTS: We identified 38 484 cases of BCC and 3724 cases of SCC. Statin ever use was associated with ORs of 1.09 (CI: 1.06–1.13) for BCC and 1.01 (CI: 0.91–1.11) for SCC. CONCLUSIONS: Statin use was not associated with risk of SCC. Residual confounding plausibly explains the marginally increased risk of BCC. Nature Publishing Group 2015-01-06 2014-10-07 /pmc/articles/PMC4453598/ /pubmed/25290087 http://dx.doi.org/10.1038/bjc.2014.527 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Short Communication
Arnspang, S
Pottegård, A
Friis, S
Clemmensen, O
Andersen, K E
Hallas, J
Gaist, D
Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark
title Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark
title_full Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark
title_fullStr Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark
title_full_unstemmed Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark
title_short Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark
title_sort statin use and risk of nonmelanoma skin cancer: a nationwide study in denmark
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453598/
https://www.ncbi.nlm.nih.gov/pubmed/25290087
http://dx.doi.org/10.1038/bjc.2014.527
work_keys_str_mv AT arnspangs statinuseandriskofnonmelanomaskincanceranationwidestudyindenmark
AT pottegarda statinuseandriskofnonmelanomaskincanceranationwidestudyindenmark
AT friiss statinuseandriskofnonmelanomaskincanceranationwidestudyindenmark
AT clemmenseno statinuseandriskofnonmelanomaskincanceranationwidestudyindenmark
AT andersenke statinuseandriskofnonmelanomaskincanceranationwidestudyindenmark
AT hallasj statinuseandriskofnonmelanomaskincanceranationwidestudyindenmark
AT gaistd statinuseandriskofnonmelanomaskincanceranationwidestudyindenmark

Ejemplares similares