The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC

BACKGROUND: Constitutive Wnt activation is essential for colorectal cancer (CRC) initiation but also underlies the cancer stem cell phenotype, metastasis and chemosensitivity. Importantly Wnt activity is still modulated as evidenced by higher Wnt activity at the invasive front of clonal tumours term...

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Detalles Bibliográficos
Autores principales: Voorneveld, P W, Kodach, L L, Jacobs, R J, van Noesel, C J M, Peppelenbosch, M P, Korkmaz, K S, Molendijk, I, Dekker, E, Morreau, H, van Pelt, G W, Tollenaar, R A E M, Mesker, W, Hawinkels, L J A C, Paauwe, M, Verspaget, H W, Geraets, D T, Hommes, D W, Offerhaus, G J A, van den Brink, G R, ten Dijke, P, Hardwick, J C H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453609/
https://www.ncbi.nlm.nih.gov/pubmed/25393365
http://dx.doi.org/10.1038/bjc.2014.560

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