Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

BACKGROUND: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. METHODS: We conducted a nested case–control study in the European Prospective Investigation into Cancer an...

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Autores principales: Ose, J, Fortner, R T, Schock, H, Peeters, P H, Onland-Moret, N C, Bueno-de-Mesquita, H B, Weiderpass, E, Gram, I T, Overvad, K, Tjonneland, A, Dossus, L, Fournier, A, Baglietto, L, Trichopoulou, A, Benetou, V, Trichopoulos, D, Boeing, H, Masala, G, Krogh, V, Matiello, A, Tumino, R, Popovic, M, Obón-Santacana, M, Larrañaga, N, Ardanaz, E, Sánchez, M-J, Menéndez, V, Chirlaque, M-D, Travis, R C, Khaw, K-T, Brändstedt, J, Idahl, A, Lundin, E, Rinaldi, S, Kuhn, E, Romieu, I, Gunter, M J, Merritt, M A, Riboli, E, Kaaks, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453611/
https://www.ncbi.nlm.nih.gov/pubmed/25349976
http://dx.doi.org/10.1038/bjc.2014.566
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author Ose, J
Fortner, R T
Schock, H
Peeters, P H
Onland-Moret, N C
Bueno-de-Mesquita, H B
Weiderpass, E
Gram, I T
Overvad, K
Tjonneland, A
Dossus, L
Fournier, A
Baglietto, L
Trichopoulou, A
Benetou, V
Trichopoulos, D
Boeing, H
Masala, G
Krogh, V
Matiello, A
Tumino, R
Popovic, M
Obón-Santacana, M
Larrañaga, N
Ardanaz, E
Sánchez, M-J
Menéndez, V
Chirlaque, M-D
Travis, R C
Khaw, K-T
Brändstedt, J
Idahl, A
Lundin, E
Rinaldi, S
Kuhn, E
Romieu, I
Gunter, M J
Merritt, M A
Riboli, E
Kaaks, R
author_facet Ose, J
Fortner, R T
Schock, H
Peeters, P H
Onland-Moret, N C
Bueno-de-Mesquita, H B
Weiderpass, E
Gram, I T
Overvad, K
Tjonneland, A
Dossus, L
Fournier, A
Baglietto, L
Trichopoulou, A
Benetou, V
Trichopoulos, D
Boeing, H
Masala, G
Krogh, V
Matiello, A
Tumino, R
Popovic, M
Obón-Santacana, M
Larrañaga, N
Ardanaz, E
Sánchez, M-J
Menéndez, V
Chirlaque, M-D
Travis, R C
Khaw, K-T
Brändstedt, J
Idahl, A
Lundin, E
Rinaldi, S
Kuhn, E
Romieu, I
Gunter, M J
Merritt, M A
Riboli, E
Kaaks, R
author_sort Ose, J
collection PubMed
description BACKGROUND: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. METHODS: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. RESULTS: We observed no association between IGF-I and EOC overall or by tumour characteristics. CONCLUSIONS: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
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spelling pubmed-44536112016-01-06 Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort Ose, J Fortner, R T Schock, H Peeters, P H Onland-Moret, N C Bueno-de-Mesquita, H B Weiderpass, E Gram, I T Overvad, K Tjonneland, A Dossus, L Fournier, A Baglietto, L Trichopoulou, A Benetou, V Trichopoulos, D Boeing, H Masala, G Krogh, V Matiello, A Tumino, R Popovic, M Obón-Santacana, M Larrañaga, N Ardanaz, E Sánchez, M-J Menéndez, V Chirlaque, M-D Travis, R C Khaw, K-T Brändstedt, J Idahl, A Lundin, E Rinaldi, S Kuhn, E Romieu, I Gunter, M J Merritt, M A Riboli, E Kaaks, R Br J Cancer Epidemiology BACKGROUND: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. METHODS: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. RESULTS: We observed no association between IGF-I and EOC overall or by tumour characteristics. CONCLUSIONS: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk. Nature Publishing Group 2015-01-06 2014-11-04 /pmc/articles/PMC4453611/ /pubmed/25349976 http://dx.doi.org/10.1038/bjc.2014.566 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Ose, J
Fortner, R T
Schock, H
Peeters, P H
Onland-Moret, N C
Bueno-de-Mesquita, H B
Weiderpass, E
Gram, I T
Overvad, K
Tjonneland, A
Dossus, L
Fournier, A
Baglietto, L
Trichopoulou, A
Benetou, V
Trichopoulos, D
Boeing, H
Masala, G
Krogh, V
Matiello, A
Tumino, R
Popovic, M
Obón-Santacana, M
Larrañaga, N
Ardanaz, E
Sánchez, M-J
Menéndez, V
Chirlaque, M-D
Travis, R C
Khaw, K-T
Brändstedt, J
Idahl, A
Lundin, E
Rinaldi, S
Kuhn, E
Romieu, I
Gunter, M J
Merritt, M A
Riboli, E
Kaaks, R
Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort
title Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort
title_full Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort
title_fullStr Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort
title_full_unstemmed Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort
title_short Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort
title_sort insulin-like growth factor i and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the epic cohort
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453611/
https://www.ncbi.nlm.nih.gov/pubmed/25349976
http://dx.doi.org/10.1038/bjc.2014.566
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