Physical function as a prognostic biomarker among cancer survivors

BACKGROUND: We tested the hypothesis that objectively measured physical function predicts mortality among cancer survivors. METHODS: We assessed objectively measured physical function including the short physical performance battery (SPPB) and fast walk speed in older adult cancer survivors. RESULTS...

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Detalles Bibliográficos
Autores principales: Brown, J C, Harhay, M O, Harhay, M N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453612/
https://www.ncbi.nlm.nih.gov/pubmed/25393366
http://dx.doi.org/10.1038/bjc.2014.568
Descripción
Sumario:BACKGROUND: We tested the hypothesis that objectively measured physical function predicts mortality among cancer survivors. METHODS: We assessed objectively measured physical function including the short physical performance battery (SPPB) and fast walk speed in older adult cancer survivors. RESULTS: Among 413 cancer survivors, 315 (76%) died during a median follow-up of 11.0 years. In multivariable-adjusted analyses, each 1-unit increase in the SPPB score and 0.1 m s(−1) increase in fast walk speed predicted a 12% reduction in mortality (hazard ratio (HR): 0.88 (95% confidence interval (CI): 0.82–0.94); P<0.001, and HR: 0.88 (95% CI: 0.82–0.96); P=0.003, respectively). CONCLUSIONS: Objectively measured physical function may predict mortality among cancer survivors.

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