Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts

BACKGROUND: A subset of human hepatocellular carcinomas (HCC) exhibit mutations of β-catenin gene CTNNB1 and overexpress Glutamine synthetase (GS). The CTNNB1-mutated HCC cell line HepG2 is sensitive to glutamine starvation induced in vitro with the antileukemic drug Crisantaspase and the GS inhibit...

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Detalles Bibliográficos
Autores principales: Chiu, M, Tardito, S, Pillozzi, S, Arcangeli, A, Armento, A, Uggeri, J, Missale, G, Bianchi, M G, Barilli, A, Dall'Asta, V, Campanini, N, Silini, E M, Fuchs, J, Armeanu-Ebinger, S, Bussolati, O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453854/
https://www.ncbi.nlm.nih.gov/pubmed/25072259
http://dx.doi.org/10.1038/bjc.2014.425

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