Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung

BACKGROUND: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis. MATERIAL AND METHODS: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs). RESULTS: The metastasis suppressor 1 was...

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Autores principales: Kayser, G, Csanadi, A, Kakanou, S, Prasse, A, Kassem, A, Stickeler, E, Passlick, B, zur Hausen, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453956/
https://www.ncbi.nlm.nih.gov/pubmed/25625275
http://dx.doi.org/10.1038/bjc.2015.2
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author Kayser, G
Csanadi, A
Kakanou, S
Prasse, A
Kassem, A
Stickeler, E
Passlick, B
zur Hausen, A
author_facet Kayser, G
Csanadi, A
Kakanou, S
Prasse, A
Kassem, A
Stickeler, E
Passlick, B
zur Hausen, A
author_sort Kayser, G
collection PubMed
description BACKGROUND: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis. MATERIAL AND METHODS: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs). RESULTS: The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung (P=0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage (P=0.019) and histological grading (P<0.001). NSCLC with MTSS1 downregulation (<20%) showed a significantly worse outcome (P=0.007). This proved to be an independent prognostic factor in squamous cell carcinomas (SCCs; P=0.041), especially in early cancer stages (P=0.006). CONCLUSION: The metastasis suppressor 1 downregulation could thus serve as a stratifying marker for adjuvant therapy in early-stage SCC of the lung.
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spelling pubmed-44539562016-03-03 Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung Kayser, G Csanadi, A Kakanou, S Prasse, A Kassem, A Stickeler, E Passlick, B zur Hausen, A Br J Cancer Molecular Diagnostics BACKGROUND: The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis. MATERIAL AND METHODS: Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs). RESULTS: The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung (P=0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage (P=0.019) and histological grading (P<0.001). NSCLC with MTSS1 downregulation (<20%) showed a significantly worse outcome (P=0.007). This proved to be an independent prognostic factor in squamous cell carcinomas (SCCs; P=0.041), especially in early cancer stages (P=0.006). CONCLUSION: The metastasis suppressor 1 downregulation could thus serve as a stratifying marker for adjuvant therapy in early-stage SCC of the lung. Nature Publishing Group 2015-03-03 2015-01-27 /pmc/articles/PMC4453956/ /pubmed/25625275 http://dx.doi.org/10.1038/bjc.2015.2 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Molecular Diagnostics
Kayser, G
Csanadi, A
Kakanou, S
Prasse, A
Kassem, A
Stickeler, E
Passlick, B
zur Hausen, A
Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung
title Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung
title_full Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung
title_fullStr Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung
title_full_unstemmed Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung
title_short Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung
title_sort downregulation of mtss1 expression is an independent prognosticator in squamous cell carcinoma of the lung
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453956/
https://www.ncbi.nlm.nih.gov/pubmed/25625275
http://dx.doi.org/10.1038/bjc.2015.2
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