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Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women

To investigate whether mitochondrial DNA haplogroups M or N are related to occurrence or manifestations of systemic lupus erythematosus (SLE), we collected M/N haplogrouping and clinical characteristics from 868 Han Chinese women with SLE, as well as for 870 age-matched healthy Han Chinese control w...

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Autores principales: Tang, Youzhou, Wang, Li, Zhu, Min, Yang, Ming, Zhong, Kuangbiao, Du, Qing, Zhang, Hao, Gui, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454022/
https://www.ncbi.nlm.nih.gov/pubmed/26039690
http://dx.doi.org/10.1038/srep10817
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author Tang, Youzhou
Wang, Li
Zhu, Min
Yang, Ming
Zhong, Kuangbiao
Du, Qing
Zhang, Hao
Gui, Ming
author_facet Tang, Youzhou
Wang, Li
Zhu, Min
Yang, Ming
Zhong, Kuangbiao
Du, Qing
Zhang, Hao
Gui, Ming
author_sort Tang, Youzhou
collection PubMed
description To investigate whether mitochondrial DNA haplogroups M or N are related to occurrence or manifestations of systemic lupus erythematosus (SLE), we collected M/N haplogrouping and clinical characteristics from 868 Han Chinese women with SLE, as well as for 870 age-matched healthy Han Chinese control women. M/N haplogroups were determined in all subjects using allele-specific amplification. The frequency of M haplogroup in all patients was 429 (49.4%) and the frequency of N haplogroup, 439 (50.6%). The corresponding frequencies in controls were 456 (52.4%) and 414 (47.6%) (P = 0.213). Among women older than 50 years at onset age, the N haplogroup was significantly higher in patients than in healthy controls (59.6% vs 41.7%, P = 0.042). The N haplogroup was associated with significantly higher risk for certain SLE characteristics: hematological system damage (OR 2.128, 95%CI 1.610 to 2.813), skin impairment (OR 1.873, 95%CI 1.428 to 2.457), neurological disturbance (OR 3.956, 95%CI 1.874 to 8.352) and alopecia (OR 1.322, 95%CI 1.007 to 1.737 ). Our results suggest that in Han Chinese women, the mtDNA N haplogroup is associated with higher risk of late-onset SLE, skin impairment, neurological disturbance, hematological system damage and alopecia.
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spelling pubmed-44540222015-06-10 Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women Tang, Youzhou Wang, Li Zhu, Min Yang, Ming Zhong, Kuangbiao Du, Qing Zhang, Hao Gui, Ming Sci Rep Article To investigate whether mitochondrial DNA haplogroups M or N are related to occurrence or manifestations of systemic lupus erythematosus (SLE), we collected M/N haplogrouping and clinical characteristics from 868 Han Chinese women with SLE, as well as for 870 age-matched healthy Han Chinese control women. M/N haplogroups were determined in all subjects using allele-specific amplification. The frequency of M haplogroup in all patients was 429 (49.4%) and the frequency of N haplogroup, 439 (50.6%). The corresponding frequencies in controls were 456 (52.4%) and 414 (47.6%) (P = 0.213). Among women older than 50 years at onset age, the N haplogroup was significantly higher in patients than in healthy controls (59.6% vs 41.7%, P = 0.042). The N haplogroup was associated with significantly higher risk for certain SLE characteristics: hematological system damage (OR 2.128, 95%CI 1.610 to 2.813), skin impairment (OR 1.873, 95%CI 1.428 to 2.457), neurological disturbance (OR 3.956, 95%CI 1.874 to 8.352) and alopecia (OR 1.322, 95%CI 1.007 to 1.737 ). Our results suggest that in Han Chinese women, the mtDNA N haplogroup is associated with higher risk of late-onset SLE, skin impairment, neurological disturbance, hematological system damage and alopecia. Nature Publishing Group 2015-06-03 /pmc/articles/PMC4454022/ /pubmed/26039690 http://dx.doi.org/10.1038/srep10817 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Tang, Youzhou
Wang, Li
Zhu, Min
Yang, Ming
Zhong, Kuangbiao
Du, Qing
Zhang, Hao
Gui, Ming
Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women
title Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women
title_full Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women
title_fullStr Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women
title_full_unstemmed Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women
title_short Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women
title_sort association of mtdna m/n haplogroups with systemic lupus erythematosus: a case-control study of han chinese women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454022/
https://www.ncbi.nlm.nih.gov/pubmed/26039690
http://dx.doi.org/10.1038/srep10817
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