TLR4-mediated inflammation promotes foam cell formation of vascular smooth muscle cell by upregulating ACAT1 expression

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Vascular smooth muscle cell (VSMC) foam cell formation is an important hallmark, especially in advanced atherosclerosis lesions. Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) promotes foam cell formation by promoting intracellular cholesteryl ester synthesis. The present study tests the hypo...

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Detalles Bibliográficos
Autores principales: Yin, Y-W, Liao, S-Q, Zhang, M-J, Liu, Y, Li, B-H, Zhou, Y, Chen, L, Gao, C-Y, Li, J-C, Zhang, L-L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454165/
https://www.ncbi.nlm.nih.gov/pubmed/25522268
http://dx.doi.org/10.1038/cddis.2014.535
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