KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage

The Chk1 protein kinase is activated in response to DNA damage through ATR-mediated phosphorylation at multiple serine-glutamine (SQ) residues within the C-terminal regulatory domain, however the molecular mechanism is not understood. Modelling indicates a high probability that this region of Chk1 c...

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Detalles Bibliográficos
Autores principales: Gong, Eun-Yeung, Smits, Veronique A. J., Fumagallo, Felipe, Piscitello, Desiree, Morrice, Nick, Freire, Raimundo, Gillespie, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454167/
https://www.ncbi.nlm.nih.gov/pubmed/26039276
http://dx.doi.org/10.1038/srep10856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454167/
https://www.ncbi.nlm.nih.gov/pubmed/26039276
http://dx.doi.org/10.1038/srep10856

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