Positive feedback between oncogenic KRAS and HIF-1α confers drug resistance in colorectal cancer

Approximately 30%–50% of colorectal cancers (CRCs) harbor the somatic mutated KRAS gene. KRAS G12V, one of the most common KRAS mutations in CRCs, is linked to increased tumor aggressiveness, less response to anti-epidermal growth factor receptor (EGFR) therapy, and poor survival rate. In this study...

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Detalles Bibliográficos
Autores principales: Wang, Yanzhao, Lei, Fuming, Rong, Wanshui, Zeng, Qingmin, Sun, Wenbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454194/
https://www.ncbi.nlm.nih.gov/pubmed/26060408
http://dx.doi.org/10.2147/OTT.S80017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454194/
https://www.ncbi.nlm.nih.gov/pubmed/26060408
http://dx.doi.org/10.2147/OTT.S80017

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