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Improving the therapeutic potential of endostatin by fusing it with the BAX BH3 death domain

Endostatin (ES) inhibits angiogenesis, reducing tumor growth in animal models. However, it has low therapeutic effect in human clinical trials. BAX is a member of the BCL-2 family of proteins; its proapoptotic (BH3) domain interacts with other members of the family in the cytoplasm, to induce apopto...

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Detalles Bibliográficos
Autores principales:	Chura-Chambi, R M, Bellini, M H, Jacysyn, J F, Andrade, L N, Medina, L P, Prieto-da-Silva, Á R B, Amarante-Mendes, G P, Morganti, L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454297/ https://www.ncbi.nlm.nih.gov/pubmed/25118931 http://dx.doi.org/10.1038/cddis.2014.309

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