Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease

Mutations in the PARK2 gene are associated with an autosomal recessive form of juvenile parkinsonism (AR-JP). These mutations affect parkin solubility and impair its E3 ligase activity, leading to a toxic accumulation of proteins within susceptible neurons that results in a slow but progressive neur...

Descripción completa

Detalles Bibliográficos
Autores principales: Romaní-Aumedes, J, Canal, M, Martín-Flores, N, Sun, X, Pérez-Fernández, V, Wewering, S, Fernández-Santiago, R, Ezquerra, M, Pont-Sunyer, C, Lafuente, A, Alberch, J, Luebbert, H, Tolosa, E, Levy, O A, Greene, L A, Malagelada, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454308/
https://www.ncbi.nlm.nih.gov/pubmed/25101677
http://dx.doi.org/10.1038/cddis.2014.333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454308/
https://www.ncbi.nlm.nih.gov/pubmed/25101677
http://dx.doi.org/10.1038/cddis.2014.333

Ejemplares similares