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Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

Accumulating evidence indicates that loss of physiologic amyloid precursor protein (APP) function leads to reduced neuronal plasticity, diminished synaptic signaling and enhanced susceptibility of neurons to cellular stress during brain aging. Here we investigated the neuroprotective function of the...

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Detalles Bibliográficos
Autores principales:	Milosch, N, Tanriöver, G, Kundu, A, Rami, A, François, J-C, Baumkötter, F, Weyer, S W, Samanta, A, Jäschke, A, Brod, F, Buchholz, C J, Kins, S, Behl, C, Müller, U C, Kögel, D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454324/ https://www.ncbi.nlm.nih.gov/pubmed/25165877 http://dx.doi.org/10.1038/cddis.2014.352

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