The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress

The unfolded protein response (UPR) is activated in neurodegenerative tauopathies such as Alzheimer's disease (AD) in close connection with early stages of tau pathology. Metabolic disturbances are strongly associated with increased risk for AD and are a potent inducer of the UPR. Here, we demo...

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Detalles Bibliográficos
Autores principales: van der Harg, J M, Nölle, A, Zwart, R, Boerema, A S, van Haastert, E S, Strijkstra, A M, Hoozemans, J JM, Scheper, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454326/
https://www.ncbi.nlm.nih.gov/pubmed/25165879
http://dx.doi.org/10.1038/cddis.2014.354

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