RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications

The inhibitory potency of an antisense oligonucleotide depends critically on its design and the accessibility of its target site. Here, we used an RNA interference-guided approach to select antisense oligonucleotide target sites in the coding region of the highly structured hepatitis C virus (HCV) R...

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Detalles Bibliográficos
Autores principales: Mutso, Margit, Nikonov, Andrei, Pihlak, Arno, Žusinaite, Eva, Viru, Liane, Selyutina, Anastasia, Reintamm, Tõnu, Kelve, Merike, Saarma, Mart, Karelson, Mati, Merits, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454572/
https://www.ncbi.nlm.nih.gov/pubmed/26039055
http://dx.doi.org/10.1371/journal.pone.0128686

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