Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes

DNA methylation is an epigenetic mark associated with regulation of transcription and genome structure. These markers have been investigated in a variety of cancer settings for their utility in differentiating normal tissue from tumor tissue. Here, we examine the direct correlation between DNA methy...

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Autores principales: Thompson, Michael J., Rubbi, Liudmilla, Dawson, David W., Donahue, Timothy R., Pellegrini, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454596/
https://www.ncbi.nlm.nih.gov/pubmed/26039411
http://dx.doi.org/10.1371/journal.pone.0128814
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author Thompson, Michael J.
Rubbi, Liudmilla
Dawson, David W.
Donahue, Timothy R.
Pellegrini, Matteo
author_facet Thompson, Michael J.
Rubbi, Liudmilla
Dawson, David W.
Donahue, Timothy R.
Pellegrini, Matteo
author_sort Thompson, Michael J.
collection PubMed
description DNA methylation is an epigenetic mark associated with regulation of transcription and genome structure. These markers have been investigated in a variety of cancer settings for their utility in differentiating normal tissue from tumor tissue. Here, we examine the direct correlation between DNA methylation and patient survival. We find that changes in the DNA methylation of key pancreatic developmental genes are strongly associated with patient survival.
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spelling pubmed-44545962015-06-09 Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes Thompson, Michael J. Rubbi, Liudmilla Dawson, David W. Donahue, Timothy R. Pellegrini, Matteo PLoS One Research Article DNA methylation is an epigenetic mark associated with regulation of transcription and genome structure. These markers have been investigated in a variety of cancer settings for their utility in differentiating normal tissue from tumor tissue. Here, we examine the direct correlation between DNA methylation and patient survival. We find that changes in the DNA methylation of key pancreatic developmental genes are strongly associated with patient survival. Public Library of Science 2015-06-03 /pmc/articles/PMC4454596/ /pubmed/26039411 http://dx.doi.org/10.1371/journal.pone.0128814 Text en © 2015 Thompson et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Thompson, Michael J.
Rubbi, Liudmilla
Dawson, David W.
Donahue, Timothy R.
Pellegrini, Matteo
Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes
title Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes
title_full Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes
title_fullStr Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes
title_full_unstemmed Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes
title_short Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes
title_sort pancreatic cancer patient survival correlates with dna methylation of pancreas development genes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454596/
https://www.ncbi.nlm.nih.gov/pubmed/26039411
http://dx.doi.org/10.1371/journal.pone.0128814
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