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Nonsecretory Multiple Myeloma and AL Amyloidosis Presenting with Nephrotic Range Proteinuria
Nonsecretory multiple myeloma (NSMM) is the absence of a detectable monoclonal protein in serum and urine of a multiple myeloma (MM) patient and immunoglobulin light chain (AL) amyloidosis is a significantly rare complication. A case of NSMM with AL amyloidosis and nephrotic range proteinuria is pre...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454745/ https://www.ncbi.nlm.nih.gov/pubmed/26090243 http://dx.doi.org/10.1155/2015/635974 |
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author | Beyler Kilic, Ozlem Oguz, Ali Kemal Ergun, Ihsan Baydar, Dilek Ertoy Ayli, Meltem |
author_facet | Beyler Kilic, Ozlem Oguz, Ali Kemal Ergun, Ihsan Baydar, Dilek Ertoy Ayli, Meltem |
author_sort | Beyler Kilic, Ozlem |
collection | PubMed |
description | Nonsecretory multiple myeloma (NSMM) is the absence of a detectable monoclonal protein in serum and urine of a multiple myeloma (MM) patient and immunoglobulin light chain (AL) amyloidosis is a significantly rare complication. A case of NSMM with AL amyloidosis and nephrotic range proteinuria is presented. Sharing clinical, therapeutic, and prognostic characteristics with MM, real challenge may be during initial diagnosis of NSMM and assessment of treatment response. In elderly patients with unexplained renal dysfunction, MM should be in the differential diagnosis and the absence of a monoclonal protein should not rule out MM but should remind us of the possibility of NSMM. |
format | Online Article Text |
id | pubmed-4454745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44547452015-06-18 Nonsecretory Multiple Myeloma and AL Amyloidosis Presenting with Nephrotic Range Proteinuria Beyler Kilic, Ozlem Oguz, Ali Kemal Ergun, Ihsan Baydar, Dilek Ertoy Ayli, Meltem Case Rep Nephrol Case Report Nonsecretory multiple myeloma (NSMM) is the absence of a detectable monoclonal protein in serum and urine of a multiple myeloma (MM) patient and immunoglobulin light chain (AL) amyloidosis is a significantly rare complication. A case of NSMM with AL amyloidosis and nephrotic range proteinuria is presented. Sharing clinical, therapeutic, and prognostic characteristics with MM, real challenge may be during initial diagnosis of NSMM and assessment of treatment response. In elderly patients with unexplained renal dysfunction, MM should be in the differential diagnosis and the absence of a monoclonal protein should not rule out MM but should remind us of the possibility of NSMM. Hindawi Publishing Corporation 2015 2015-05-21 /pmc/articles/PMC4454745/ /pubmed/26090243 http://dx.doi.org/10.1155/2015/635974 Text en Copyright © 2015 Ozlem Beyler Kilic et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Beyler Kilic, Ozlem Oguz, Ali Kemal Ergun, Ihsan Baydar, Dilek Ertoy Ayli, Meltem Nonsecretory Multiple Myeloma and AL Amyloidosis Presenting with Nephrotic Range Proteinuria |
title | Nonsecretory Multiple Myeloma and AL Amyloidosis Presenting with Nephrotic Range Proteinuria |
title_full | Nonsecretory Multiple Myeloma and AL Amyloidosis Presenting with Nephrotic Range Proteinuria |
title_fullStr | Nonsecretory Multiple Myeloma and AL Amyloidosis Presenting with Nephrotic Range Proteinuria |
title_full_unstemmed | Nonsecretory Multiple Myeloma and AL Amyloidosis Presenting with Nephrotic Range Proteinuria |
title_short | Nonsecretory Multiple Myeloma and AL Amyloidosis Presenting with Nephrotic Range Proteinuria |
title_sort | nonsecretory multiple myeloma and al amyloidosis presenting with nephrotic range proteinuria |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454745/ https://www.ncbi.nlm.nih.gov/pubmed/26090243 http://dx.doi.org/10.1155/2015/635974 |
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