LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal

CONTEXT: Aldosterone synthesis and cellularity in the human adrenal zona glomerulosa (ZG) is sparse and patchy, presumably due to salt excess. The frequency of somatic mutations causing aldosterone-producing adenomas (APAs) may be a consequence of protection from cell loss by constitutive aldosteron...

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Autores principales: Shaikh, Lalarukh Haris, Zhou, Junhua, Teo, Ada E. D., Garg, Sumedha, Neogi, Sudeshna Guha, Figg, Nichola, Yeo, Giles S., Yu, Haixiang, Maguire, Janet J., Zhao, Wanfeng, Bennett, Martin R., Azizan, Elena A. B., Davenport, Anthony P., McKenzie, Grahame, Brown, Morris J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2015
Materias:
Hot Topics in Translational Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454794/
https://www.ncbi.nlm.nih.gov/pubmed/25915569
http://dx.doi.org/10.1210/jc.2015-1734

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