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Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation

This study aimed to determine if naturally occurring episodes of ozone air pollution in the Salt Lake Valley in Utah, USA, during the summer are associated with increased pulmonary inflammation and oxidative stress, increased respiratory symptoms, and decreased lung function in individuals with chro...

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Autores principales: Pirozzi, Cheryl, Sturrock, Anne, Weng, Hsin-Yi, Greene, Tom, Scholand, Mary Beth, Kanner, Richard, Paine, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454954/
https://www.ncbi.nlm.nih.gov/pubmed/25985308
http://dx.doi.org/10.3390/ijerph120505061
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author Pirozzi, Cheryl
Sturrock, Anne
Weng, Hsin-Yi
Greene, Tom
Scholand, Mary Beth
Kanner, Richard
Paine, Robert
author_facet Pirozzi, Cheryl
Sturrock, Anne
Weng, Hsin-Yi
Greene, Tom
Scholand, Mary Beth
Kanner, Richard
Paine, Robert
author_sort Pirozzi, Cheryl
collection PubMed
description This study aimed to determine if naturally occurring episodes of ozone air pollution in the Salt Lake Valley in Utah, USA, during the summer are associated with increased pulmonary inflammation and oxidative stress, increased respiratory symptoms, and decreased lung function in individuals with chronic obstructive pulmonary disease (COPD) compared to controls. We measured biomarkers (nitrite/nitrate (NO(x)), 8-isoprostane) in exhaled breath condensate (EBC), spirometry, and respiratory symptoms in 11 former smokers with moderate-to-severe COPD and nine former smokers without airflow obstruction during periods of low and high ozone air pollution. High ozone levels were associated with increased NO(x) in EBC in both COPD (8.7 (±8.5) vs. 28.6 (±17.6) μmol/L on clean air vs. pollution days, respectively, p < 0.01) and control participants (7.6 (±16.5) vs. 28.5 (±15.6) μmol/L on clean air vs. pollution days, respectively, p = 0.02). There was no difference in pollution effect between COPD and control groups, and no difference in EBC 8-isoprostane, pulmonary function, or respiratory symptoms between clean air and pollution days in either group. Former smokers both with and without airflow obstruction developed airway oxidative stress and inflammation in association with ozone air pollution episodes.
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spelling pubmed-44549542015-06-04 Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation Pirozzi, Cheryl Sturrock, Anne Weng, Hsin-Yi Greene, Tom Scholand, Mary Beth Kanner, Richard Paine, Robert Int J Environ Res Public Health Article This study aimed to determine if naturally occurring episodes of ozone air pollution in the Salt Lake Valley in Utah, USA, during the summer are associated with increased pulmonary inflammation and oxidative stress, increased respiratory symptoms, and decreased lung function in individuals with chronic obstructive pulmonary disease (COPD) compared to controls. We measured biomarkers (nitrite/nitrate (NO(x)), 8-isoprostane) in exhaled breath condensate (EBC), spirometry, and respiratory symptoms in 11 former smokers with moderate-to-severe COPD and nine former smokers without airflow obstruction during periods of low and high ozone air pollution. High ozone levels were associated with increased NO(x) in EBC in both COPD (8.7 (±8.5) vs. 28.6 (±17.6) μmol/L on clean air vs. pollution days, respectively, p < 0.01) and control participants (7.6 (±16.5) vs. 28.5 (±15.6) μmol/L on clean air vs. pollution days, respectively, p = 0.02). There was no difference in pollution effect between COPD and control groups, and no difference in EBC 8-isoprostane, pulmonary function, or respiratory symptoms between clean air and pollution days in either group. Former smokers both with and without airflow obstruction developed airway oxidative stress and inflammation in association with ozone air pollution episodes. MDPI 2015-05-12 2015-05 /pmc/articles/PMC4454954/ /pubmed/25985308 http://dx.doi.org/10.3390/ijerph120505061 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pirozzi, Cheryl
Sturrock, Anne
Weng, Hsin-Yi
Greene, Tom
Scholand, Mary Beth
Kanner, Richard
Paine, Robert
Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation
title Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation
title_full Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation
title_fullStr Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation
title_full_unstemmed Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation
title_short Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation
title_sort effect of naturally occurring ozone air pollution episodes on pulmonary oxidative stress and inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454954/
https://www.ncbi.nlm.nih.gov/pubmed/25985308
http://dx.doi.org/10.3390/ijerph120505061
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