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New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues
Natural peptides show high degrees of specificity in their biological action. However, their therapeutical profile is severely limited by their conformational freedom and metabolic instability. Stapled peptides constitute a solution to these problems and access to these structures lies on a limited...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455059/ https://www.ncbi.nlm.nih.gov/pubmed/25994485 http://dx.doi.org/10.1038/ncomms8160 |