Mitochondrial Ion Channels in Cancer Transformation

Cancer transformation involves reprograming of mitochondrial function to avert cell death mechanisms, monopolize energy metabolism, accelerate mitotic proliferation, and promote metastasis. Mitochondrial ion channels have emerged as promising therapeutic targets because of their connection to metabo...

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Detalles Bibliográficos
Autores principales: Madamba, Stephen M., Damri, Kevin N., Dejean, Laurent M., Peixoto, Pablo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455240/
https://www.ncbi.nlm.nih.gov/pubmed/26090338
http://dx.doi.org/10.3389/fonc.2015.00120
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author Madamba, Stephen M.
Damri, Kevin N.
Dejean, Laurent M.
Peixoto, Pablo M.
author_facet Madamba, Stephen M.
Damri, Kevin N.
Dejean, Laurent M.
Peixoto, Pablo M.
author_sort Madamba, Stephen M.
collection PubMed
description Cancer transformation involves reprograming of mitochondrial function to avert cell death mechanisms, monopolize energy metabolism, accelerate mitotic proliferation, and promote metastasis. Mitochondrial ion channels have emerged as promising therapeutic targets because of their connection to metabolic and apoptotic functions. This mini review discusses how mitochondrial channels may be associated with cancer transformation and expands on the possible involvement of mitochondrial protein import complexes in pathophysiological process.
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spelling pubmed-44552402015-06-18 Mitochondrial Ion Channels in Cancer Transformation Madamba, Stephen M. Damri, Kevin N. Dejean, Laurent M. Peixoto, Pablo M. Front Oncol Oncology Cancer transformation involves reprograming of mitochondrial function to avert cell death mechanisms, monopolize energy metabolism, accelerate mitotic proliferation, and promote metastasis. Mitochondrial ion channels have emerged as promising therapeutic targets because of their connection to metabolic and apoptotic functions. This mini review discusses how mitochondrial channels may be associated with cancer transformation and expands on the possible involvement of mitochondrial protein import complexes in pathophysiological process. Frontiers Media S.A. 2015-06-04 /pmc/articles/PMC4455240/ /pubmed/26090338 http://dx.doi.org/10.3389/fonc.2015.00120 Text en Copyright © 2015 Madamba, Damri, Dejean and Peixoto. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Madamba, Stephen M.
Damri, Kevin N.
Dejean, Laurent M.
Peixoto, Pablo M.
Mitochondrial Ion Channels in Cancer Transformation
title Mitochondrial Ion Channels in Cancer Transformation
title_full Mitochondrial Ion Channels in Cancer Transformation
title_fullStr Mitochondrial Ion Channels in Cancer Transformation
title_full_unstemmed Mitochondrial Ion Channels in Cancer Transformation
title_short Mitochondrial Ion Channels in Cancer Transformation
title_sort mitochondrial ion channels in cancer transformation
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455240/
https://www.ncbi.nlm.nih.gov/pubmed/26090338
http://dx.doi.org/10.3389/fonc.2015.00120
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AT peixotopablom mitochondrialionchannelsincancertransformation

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