Cargando…

TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPARγ2

TonEBP is a key transcription factor in cellular adaptation to hypertonic stress, and also in macrophage activation. Since TonEBP is involved in inflammatory diseases such as rheumatoid arthritis and atherosclerosis, we asked whether TonEBP played a role in adipogenesis and insulin resistance. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ho Lee, Jun, Hee Lee, Hwan, Jin Ye, Byeong, Lee-Kwon, Whaseon, Youn Choi, Soo, Moo Kwon, Hyug
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455245/ https://www.ncbi.nlm.nih.gov/pubmed/26042523 http://dx.doi.org/10.1038/srep10937

Ejemplares similares

Modulation of TonEBP activity by SUMO modification in response to hypertonicity
por: Kim, Jeong-Ah, et al.
Publicado: (2014)

TonEBP suppresses IL-10-mediated immunomodulation
por: Choi, Soo Youn, et al.
Publicado: (2016)

TonEBP and SMIT expression in human placenta
por: Shin, Jung-A, et al.
Publicado: (2012)

TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter
por: Yoo, Eun Jin, et al.
Publicado: (2019)

TonEBP Promotes β-Cell Survival under ER Stress by Enhancing Autophagy
por: Kang, Hyun Je, et al.
Publicado: (2020)

TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
por: Lee, Hwan Hee, et al.
Publicado: (2019)

Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-κB and AP-1
por: Jeong, Gyu Won, et al.
Publicado: (2020)

Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury
por: Yoo, Eun Jin, et al.
Publicado: (2019)

TonEBP in dendritic cells mediates pro-inflammatory maturation and Th1/Th17 responses
por: Ye, Byeong Jin, et al.
Publicado: (2020)

TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling
por: Lee, Hwan Hee, et al.
Publicado: (2022)

LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding
por: Lee, Hwan Hee, et al.
Publicado: (2016)

TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
por: Kang, Hyun Je, et al.
Publicado: (2019)

TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution
por: Kang, Hyun Je, et al.
Publicado: (2020)

Transcription Factor TonEBP Stimulates Hyperosmolality-Dependent Arginine Vasopressin Gene Expression in the Mouse Hypothalamus
por: Kim, Dong Hee, et al.
Publicado: (2021)

Osmoprotective Transcription Factor NFAT5/TonEBP Modulates Nuclear Factor-κB Activity
por: Roth, Isabelle, et al.
Publicado: (2010)

TonEBP/NFAT5 haploinsufficiency attenuates hippocampal inflammation in high-fat diet/streptozotocin-induced diabetic mice
por: Lee, Jong Youl, et al.
Publicado: (2017)

TonEBP modulates the protective effect of taurine in ischemia-induced cytotoxicity in cardiomyocytes
por: Yang, Y J, et al.
Publicado: (2015)

TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc
por: Snuggs, J. W., et al.
Publicado: (2021)

TonEBP suppresses adipocyte differentiation via modulation of early signaling in 3T3-L1 cells
por: Kim, Soo Jin, et al.
Publicado: (2016)

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus
por: Liu, Chao, et al.
Publicado: (2017)

TonEBP Haploinsufficiency Attenuates Microglial Activation and Memory Deficits in Middle-Aged and Amyloid β Oligomer-Treated Mice
por: Lee, Jong Youl, et al.
Publicado: (2023)

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP
por: Johnson, Zariel I., et al.
Publicado: (2014)

The TLR-2/TonEBP signaling pathway regulates 29-kDa fibronectin fragment-dependent expression of matrix metalloproteinases
por: Hwang, Hyun Sook, et al.
Publicado: (2021)

Involvement of TonEBP/NFAT5 in osmoadaptative response of human retinal pigmented epithelial cells to hyperosmolar stress
por: Libert, Sarah, et al.
Publicado: (2016)

TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells
por: Hödebeck, Maren, et al.
Publicado: (2014)

Focal adhesion kinase regulates the activity of the osmosensitive transcription factor TonEBP/NFAT5 under hypertonic conditions
por: Neuhofer, Wolfgang, et al.
Publicado: (2014)

Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation
por: Choi, Hyowon, et al.
Publicado: (2019)

Genistein‐Calcitriol Mitigates Hyperosmotic Stress‐Induced TonEBP, CFTR Dysfunction, VDR Degradation and Inflammation in Dry Eye Disease
por: Panigrahi, Trailokyanath, et al.
Publicado: (2020)

Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis
por: Lee, Ji-Eun, et al.
Publicado: (2014)

Osmolyte regulation by TonEBP/NFAT5 during anoxia-recovery and dehydration–rehydration stresses in the freeze-tolerant wood frog (Rana sylvatica)
por: Al-attar, Rasha, et al.
Publicado: (2017)

Mediator of DNA Damage Checkpoint 1 (MDC1) Contributes to High NaCl-Induced Activation of the Osmoprotective Transcription Factor TonEBP/OREBP
por: Kunin, Margarita, et al.
Publicado: (2010)

NFAT5/TonEBP Limits Pulmonary Vascular Resistance in the Hypoxic Lung by Controlling Mitochondrial Reactive Oxygen Species Generation in Arterial Smooth Muscle Cells
por: Laban, Hebatullah, et al.
Publicado: (2021)

Laquinimod Prevents Adipogenesis and Obesity by Down-Regulating PPAR-γ and C/EBPα through Activating AMPK
por: Wang, Guang, et al.
Publicado: (2020)

Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARγ pathways
por: Liang, Yu-Chuan, et al.
Publicado: (2016)

Heat-Killed Enterococcus faecalis Prevents Adipogenesis and High Fat Diet-Induced Obesity by Inhibition of Lipid Accumulation through Inhibiting C/EBP-α and PPAR-γ in the Insulin Signaling Pathway
por: Lee, Jin-Ho, et al.
Publicado: (2022)

High NaCl–induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization
por: Gallazzini, Morgan, et al.
Publicado: (2011)

Prostaglandins as PPARγ Modulators in Adipogenesis
por: Fujimori, Ko
Publicado: (2012)

Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ
por: Zhu, Qi, et al.
Publicado: (2022)

Hyperglycemia Changes Expression of Key Adipogenesis Markers (C/EBPα and PPARᵞ)and Morphology of Differentiating Human Visceral Adipocytes
por: Świderska, Ewa, et al.
Publicado: (2019)

Derhamnosylmaysin Inhibits Adipogenesis via Inhibiting Expression of PPARγ and C/EBPα in 3T3-L1 Cells
por: Cho, Hang-Hee, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3a6oua0fptlvdi6rvt89gdk8qt