GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson’s disease via its RGS homology domain

Degeneration of dopaminergic neurons causes Parkinson’s disease. Dopamine replacement therapy with L-DOPA is the best available treatment. However, patients develop L-DOPA-induced dyskinesia (LID). In the hemiparkinsonian rat, chronic L-DOPA increases rotations and abnormal involuntary movements mod...

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Detalles Bibliográficos
Autores principales: Ahmed, Mohamed R., Bychkov, Evgeny, Li, Lingyong, Gurevich, Vsevolod V., Gurevich, Eugenia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455246/
https://www.ncbi.nlm.nih.gov/pubmed/26043205
http://dx.doi.org/10.1038/srep10920

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