Cargando…

Arsenic-induced dyslipidemia in male albino rats: comparison between trivalent and pentavalent inorganic arsenic in drinking water

BACKGROUND: Recent epidemiological evidences indicate close association between inorganic arsenic exposure via drinking water and cardiovascular diseases. However, the exact mechanism of this arsenic-mediated increase in cardiovascular risk factors remains enigmatic. METHODS: In order to investigate...

Descripción completa

Detalles Bibliográficos
Autores principales: Afolabi, Olusegun K., Wusu, Adedoja D., Ogunrinola, Olabisi O., Abam, Esther O., Babayemi, David O., Dosumu, Oluwatosin. A., Onunkwor, Okechukwu. B., Balogun, Elizabeth. A., Odukoya, Olusegun O., Ademuyiwa, Oladipo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455335/
https://www.ncbi.nlm.nih.gov/pubmed/26044777
http://dx.doi.org/10.1186/s40360-015-0015-z
_version_ 1782374746757791744
author Afolabi, Olusegun K.
Wusu, Adedoja D.
Ogunrinola, Olabisi O.
Abam, Esther O.
Babayemi, David O.
Dosumu, Oluwatosin. A.
Onunkwor, Okechukwu. B.
Balogun, Elizabeth. A.
Odukoya, Olusegun O.
Ademuyiwa, Oladipo
author_facet Afolabi, Olusegun K.
Wusu, Adedoja D.
Ogunrinola, Olabisi O.
Abam, Esther O.
Babayemi, David O.
Dosumu, Oluwatosin. A.
Onunkwor, Okechukwu. B.
Balogun, Elizabeth. A.
Odukoya, Olusegun O.
Ademuyiwa, Oladipo
author_sort Afolabi, Olusegun K.
collection PubMed
description BACKGROUND: Recent epidemiological evidences indicate close association between inorganic arsenic exposure via drinking water and cardiovascular diseases. However, the exact mechanism of this arsenic-mediated increase in cardiovascular risk factors remains enigmatic. METHODS: In order to investigate the effects of inorganic arsenic exposure on lipid metabolism, male albino rats were exposed to 50, 100 and 150 ppm arsenic as sodium arsenite and 100, 150 and 200 ppm arsenic as sodium arsenate respectively in their drinking water for 12 weeks. RESULTS: Dyslipidemia induced by the two arsenicals exhibited different patterns. Hypocholesterolemia characterised the effect of arsenite at all the doses, but arsenate induced hypercholesterolemia at the 150 ppm As dose. Hypertriglyceridemia was the hallmark of arsenate effect whereas plasma free fatty acids (FFAs) was increased by the two arsenicals. Reverse cholesterol transport was inhibited by the two arsenicals as evidenced by decreased HDL cholesterol concentrations whereas hepatic cholesterol was increased by arsenite (100 ppm As), but decreased by arsenite (150 ppm As) and arsenate (100 ppm As) respectively. Brain cholesterol and triglyceride were decreased by the two arsenicals; arsenate decreased the renal content of cholesterol, but increased renal content of triglyceride. Arsenite, on the other hand, increased the renal contents of the two lipids. The two arsenicals induced phospholipidosis in the spleen. Arsenite (150 ppm As) and arsenate (100 ppm As) inhibited hepatic HMG CoA reductase. At other doses of the two arsenicals, hepatic activity of the enzyme was up-regulated. The two arsenicals however up-regulated the activity of the brain enzyme. We observed positive associations between tissue arsenic levels and plasma FFA and negative associations between tissue arsenic levels and HDL cholesterol. CONCLUSION: Our findings indicate that even though sub-chronic exposure to arsenite and arsenate through drinking water produced different patterns of dyslipidemia, our study identified two common denominators of dyslipidemia namely: inhibition of reverse cholesterol transport and increase in plasma FFA. These two denominators (in addition to other individual perturbations of lipid metabolism induced by each arsenical), suggest that in contrast to strengthening a dose-dependent effect phenomenon, the two forms of inorganic arsenic induced lipotoxic and non-lipotoxic dyslipidemia at “low” or “medium” doses and these might be responsible for the cardiovascular and other disease endpoints of inorganic arsenic exposure through drinking water.
format Online
Article
Text
id pubmed-4455335
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-44553352015-06-05 Arsenic-induced dyslipidemia in male albino rats: comparison between trivalent and pentavalent inorganic arsenic in drinking water Afolabi, Olusegun K. Wusu, Adedoja D. Ogunrinola, Olabisi O. Abam, Esther O. Babayemi, David O. Dosumu, Oluwatosin. A. Onunkwor, Okechukwu. B. Balogun, Elizabeth. A. Odukoya, Olusegun O. Ademuyiwa, Oladipo BMC Pharmacol Toxicol Research Article BACKGROUND: Recent epidemiological evidences indicate close association between inorganic arsenic exposure via drinking water and cardiovascular diseases. However, the exact mechanism of this arsenic-mediated increase in cardiovascular risk factors remains enigmatic. METHODS: In order to investigate the effects of inorganic arsenic exposure on lipid metabolism, male albino rats were exposed to 50, 100 and 150 ppm arsenic as sodium arsenite and 100, 150 and 200 ppm arsenic as sodium arsenate respectively in their drinking water for 12 weeks. RESULTS: Dyslipidemia induced by the two arsenicals exhibited different patterns. Hypocholesterolemia characterised the effect of arsenite at all the doses, but arsenate induced hypercholesterolemia at the 150 ppm As dose. Hypertriglyceridemia was the hallmark of arsenate effect whereas plasma free fatty acids (FFAs) was increased by the two arsenicals. Reverse cholesterol transport was inhibited by the two arsenicals as evidenced by decreased HDL cholesterol concentrations whereas hepatic cholesterol was increased by arsenite (100 ppm As), but decreased by arsenite (150 ppm As) and arsenate (100 ppm As) respectively. Brain cholesterol and triglyceride were decreased by the two arsenicals; arsenate decreased the renal content of cholesterol, but increased renal content of triglyceride. Arsenite, on the other hand, increased the renal contents of the two lipids. The two arsenicals induced phospholipidosis in the spleen. Arsenite (150 ppm As) and arsenate (100 ppm As) inhibited hepatic HMG CoA reductase. At other doses of the two arsenicals, hepatic activity of the enzyme was up-regulated. The two arsenicals however up-regulated the activity of the brain enzyme. We observed positive associations between tissue arsenic levels and plasma FFA and negative associations between tissue arsenic levels and HDL cholesterol. CONCLUSION: Our findings indicate that even though sub-chronic exposure to arsenite and arsenate through drinking water produced different patterns of dyslipidemia, our study identified two common denominators of dyslipidemia namely: inhibition of reverse cholesterol transport and increase in plasma FFA. These two denominators (in addition to other individual perturbations of lipid metabolism induced by each arsenical), suggest that in contrast to strengthening a dose-dependent effect phenomenon, the two forms of inorganic arsenic induced lipotoxic and non-lipotoxic dyslipidemia at “low” or “medium” doses and these might be responsible for the cardiovascular and other disease endpoints of inorganic arsenic exposure through drinking water. BioMed Central 2015-06-05 /pmc/articles/PMC4455335/ /pubmed/26044777 http://dx.doi.org/10.1186/s40360-015-0015-z Text en © Afolabi et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Afolabi, Olusegun K.
Wusu, Adedoja D.
Ogunrinola, Olabisi O.
Abam, Esther O.
Babayemi, David O.
Dosumu, Oluwatosin. A.
Onunkwor, Okechukwu. B.
Balogun, Elizabeth. A.
Odukoya, Olusegun O.
Ademuyiwa, Oladipo
Arsenic-induced dyslipidemia in male albino rats: comparison between trivalent and pentavalent inorganic arsenic in drinking water
title Arsenic-induced dyslipidemia in male albino rats: comparison between trivalent and pentavalent inorganic arsenic in drinking water
title_full Arsenic-induced dyslipidemia in male albino rats: comparison between trivalent and pentavalent inorganic arsenic in drinking water
title_fullStr Arsenic-induced dyslipidemia in male albino rats: comparison between trivalent and pentavalent inorganic arsenic in drinking water
title_full_unstemmed Arsenic-induced dyslipidemia in male albino rats: comparison between trivalent and pentavalent inorganic arsenic in drinking water
title_short Arsenic-induced dyslipidemia in male albino rats: comparison between trivalent and pentavalent inorganic arsenic in drinking water
title_sort arsenic-induced dyslipidemia in male albino rats: comparison between trivalent and pentavalent inorganic arsenic in drinking water
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455335/
https://www.ncbi.nlm.nih.gov/pubmed/26044777
http://dx.doi.org/10.1186/s40360-015-0015-z
work_keys_str_mv AT afolabiolusegunk arsenicinduceddyslipidemiainmalealbinoratscomparisonbetweentrivalentandpentavalentinorganicarsenicindrinkingwater
AT wusuadedojad arsenicinduceddyslipidemiainmalealbinoratscomparisonbetweentrivalentandpentavalentinorganicarsenicindrinkingwater
AT ogunrinolaolabisio arsenicinduceddyslipidemiainmalealbinoratscomparisonbetweentrivalentandpentavalentinorganicarsenicindrinkingwater
AT abamesthero arsenicinduceddyslipidemiainmalealbinoratscomparisonbetweentrivalentandpentavalentinorganicarsenicindrinkingwater
AT babayemidavido arsenicinduceddyslipidemiainmalealbinoratscomparisonbetweentrivalentandpentavalentinorganicarsenicindrinkingwater
AT dosumuoluwatosina arsenicinduceddyslipidemiainmalealbinoratscomparisonbetweentrivalentandpentavalentinorganicarsenicindrinkingwater
AT onunkworokechukwub arsenicinduceddyslipidemiainmalealbinoratscomparisonbetweentrivalentandpentavalentinorganicarsenicindrinkingwater
AT balogunelizabetha arsenicinduceddyslipidemiainmalealbinoratscomparisonbetweentrivalentandpentavalentinorganicarsenicindrinkingwater
AT odukoyaoluseguno arsenicinduceddyslipidemiainmalealbinoratscomparisonbetweentrivalentandpentavalentinorganicarsenicindrinkingwater
AT ademuyiwaoladipo arsenicinduceddyslipidemiainmalealbinoratscomparisonbetweentrivalentandpentavalentinorganicarsenicindrinkingwater