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Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE)
BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma. METHODS: Asth...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
NLM-Export
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455584/ https://www.ncbi.nlm.nih.gov/pubmed/25712593 http://dx.doi.org/10.1289/ehp.1408206 |
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author | Jacquemin, Bénédicte Siroux, Valérie Sanchez, Margaux Carsin, Anne-Elie Schikowski, Tamara Adam, Martin Bellisario, Valeria Buschka, Anna Bono, Roberto Brunekreef, Bert Cai, Yutong Cirach, Marta Clavel-Chapelon, Françoise Declercq, Christophe de Marco, Roberto de Nazelle, Audrey Ducret-Stich, Regina E. Ferretti, Virginia Valeria Gerbase, Margaret W. Hardy, Rebecca Heinrich, Joachim Janson, Christer Jarvis, Deborah Al Kanaani, Zaina Keidel, Dirk Kuh, Diana Le Moual, Nicole Nieuwenhuijsen, Mark J. Marcon, Alessandro Modig, Lars Pin, Isabelle Rochat, Thierry Schindler, Christian Sugiri, Dorothea Stempfelet, Morgane Temam, Sofia Tsai, Ming-Yi Varraso, Raphaëlle Vienneau, Danielle Vierkötter, Andrea Hansell, Anna L. Krämer, Ursula Probst-Hensch, Nicole M. Sunyer, Jordi Künzli, Nino Kauffmann, Francine |
author_facet | Jacquemin, Bénédicte Siroux, Valérie Sanchez, Margaux Carsin, Anne-Elie Schikowski, Tamara Adam, Martin Bellisario, Valeria Buschka, Anna Bono, Roberto Brunekreef, Bert Cai, Yutong Cirach, Marta Clavel-Chapelon, Françoise Declercq, Christophe de Marco, Roberto de Nazelle, Audrey Ducret-Stich, Regina E. Ferretti, Virginia Valeria Gerbase, Margaret W. Hardy, Rebecca Heinrich, Joachim Janson, Christer Jarvis, Deborah Al Kanaani, Zaina Keidel, Dirk Kuh, Diana Le Moual, Nicole Nieuwenhuijsen, Mark J. Marcon, Alessandro Modig, Lars Pin, Isabelle Rochat, Thierry Schindler, Christian Sugiri, Dorothea Stempfelet, Morgane Temam, Sofia Tsai, Ming-Yi Varraso, Raphaëlle Vienneau, Danielle Vierkötter, Andrea Hansell, Anna L. Krämer, Ursula Probst-Hensch, Nicole M. Sunyer, Jordi Künzli, Nino Kauffmann, Francine |
author_sort | Jacquemin, Bénédicte |
collection | PubMed |
description | BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma. METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PM(coarse). Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m(3); p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m(3); p = 0.08). Nonsignificant positive associations were estimated for PM(10) (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m(3)), PM(2.5) (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m(3)), PM(2.5absorbance) (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10(–5)/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PM(coarse) (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m(3)). CONCLUSIONS: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed. CITATION: Jacquemin B, Siroux V, Sanchez M, Carsin AE, Schikowski T, Adam M, Bellisario V, Buschka A, Bono R, Brunekreef B, Cai Y, Cirach M, Clavel-Chapelon F, Declercq C, de Marco R, de Nazelle A, Ducret-Stich RE, Ferretti VV, Gerbase MW, Hardy R, Heinrich J, Janson C, Jarvis D, Al Kanaani Z, Keidel D, Kuh D, Le Moual N, Nieuwenhuijsen MJ, Marcon A, Modig L, Pin I, Rochat T, Schindler C, Sugiri D, Stempfelet M, Temam S, Tsai MY, Varraso R, Vienneau D, Vierkötter A, Hansell AL, Krämer U, Probst-Hensch NM, Sunyer J, Künzli N, Kauffmann F. 2015. Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE). Environ Health Perspect 123:613–621; http://dx.doi.org/10.1289/ehp.1408206 |
format | Online Article Text |
id | pubmed-4455584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | NLM-Export |
record_format | MEDLINE/PubMed |
spelling | pubmed-44555842015-06-09 Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE) Jacquemin, Bénédicte Siroux, Valérie Sanchez, Margaux Carsin, Anne-Elie Schikowski, Tamara Adam, Martin Bellisario, Valeria Buschka, Anna Bono, Roberto Brunekreef, Bert Cai, Yutong Cirach, Marta Clavel-Chapelon, Françoise Declercq, Christophe de Marco, Roberto de Nazelle, Audrey Ducret-Stich, Regina E. Ferretti, Virginia Valeria Gerbase, Margaret W. Hardy, Rebecca Heinrich, Joachim Janson, Christer Jarvis, Deborah Al Kanaani, Zaina Keidel, Dirk Kuh, Diana Le Moual, Nicole Nieuwenhuijsen, Mark J. Marcon, Alessandro Modig, Lars Pin, Isabelle Rochat, Thierry Schindler, Christian Sugiri, Dorothea Stempfelet, Morgane Temam, Sofia Tsai, Ming-Yi Varraso, Raphaëlle Vienneau, Danielle Vierkötter, Andrea Hansell, Anna L. Krämer, Ursula Probst-Hensch, Nicole M. Sunyer, Jordi Künzli, Nino Kauffmann, Francine Environ Health Perspect Research BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma. METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PM(coarse). Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m(3); p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m(3); p = 0.08). Nonsignificant positive associations were estimated for PM(10) (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m(3)), PM(2.5) (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m(3)), PM(2.5absorbance) (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10(–5)/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PM(coarse) (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m(3)). CONCLUSIONS: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed. CITATION: Jacquemin B, Siroux V, Sanchez M, Carsin AE, Schikowski T, Adam M, Bellisario V, Buschka A, Bono R, Brunekreef B, Cai Y, Cirach M, Clavel-Chapelon F, Declercq C, de Marco R, de Nazelle A, Ducret-Stich RE, Ferretti VV, Gerbase MW, Hardy R, Heinrich J, Janson C, Jarvis D, Al Kanaani Z, Keidel D, Kuh D, Le Moual N, Nieuwenhuijsen MJ, Marcon A, Modig L, Pin I, Rochat T, Schindler C, Sugiri D, Stempfelet M, Temam S, Tsai MY, Varraso R, Vienneau D, Vierkötter A, Hansell AL, Krämer U, Probst-Hensch NM, Sunyer J, Künzli N, Kauffmann F. 2015. Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE). Environ Health Perspect 123:613–621; http://dx.doi.org/10.1289/ehp.1408206 NLM-Export 2015-02-24 2015-06 /pmc/articles/PMC4455584/ /pubmed/25712593 http://dx.doi.org/10.1289/ehp.1408206 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Jacquemin, Bénédicte Siroux, Valérie Sanchez, Margaux Carsin, Anne-Elie Schikowski, Tamara Adam, Martin Bellisario, Valeria Buschka, Anna Bono, Roberto Brunekreef, Bert Cai, Yutong Cirach, Marta Clavel-Chapelon, Françoise Declercq, Christophe de Marco, Roberto de Nazelle, Audrey Ducret-Stich, Regina E. Ferretti, Virginia Valeria Gerbase, Margaret W. Hardy, Rebecca Heinrich, Joachim Janson, Christer Jarvis, Deborah Al Kanaani, Zaina Keidel, Dirk Kuh, Diana Le Moual, Nicole Nieuwenhuijsen, Mark J. Marcon, Alessandro Modig, Lars Pin, Isabelle Rochat, Thierry Schindler, Christian Sugiri, Dorothea Stempfelet, Morgane Temam, Sofia Tsai, Ming-Yi Varraso, Raphaëlle Vienneau, Danielle Vierkötter, Andrea Hansell, Anna L. Krämer, Ursula Probst-Hensch, Nicole M. Sunyer, Jordi Künzli, Nino Kauffmann, Francine Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE) |
title | Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE) |
title_full | Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE) |
title_fullStr | Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE) |
title_full_unstemmed | Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE) |
title_short | Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE) |
title_sort | ambient air pollution and adult asthma incidence in six european cohorts (escape) |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455584/ https://www.ncbi.nlm.nih.gov/pubmed/25712593 http://dx.doi.org/10.1289/ehp.1408206 |
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