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Nonsynonymous Substitution Rate Heterogeneity in the Peptide-Binding Region Among Different HLA-DRB1 Lineages in Humans
An extraordinary diversity of amino acid sequences in the peptide-binding region (PBR) of human leukocyte antigen [HLA; human major histocompatibility complex (MHC)] molecules has been maintained by balancing selection. The process of accumulation of amino acid diversity in the PBR for six HLA genes...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Genetics Society of America
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455771/ https://www.ncbi.nlm.nih.gov/pubmed/24793785 http://dx.doi.org/10.1534/g3.114.011726 |