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Nonsynonymous Substitution Rate Heterogeneity in the Peptide-Binding Region Among Different HLA-DRB1 Lineages in Humans

An extraordinary diversity of amino acid sequences in the peptide-binding region (PBR) of human leukocyte antigen [HLA; human major histocompatibility complex (MHC)] molecules has been maintained by balancing selection. The process of accumulation of amino acid diversity in the PBR for six HLA genes...

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Detalles Bibliográficos
Autores principales:	Yasukochi, Yoshiki, Satta, Yoko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2014
Materias:	Genetics of Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455771/ https://www.ncbi.nlm.nih.gov/pubmed/24793785 http://dx.doi.org/10.1534/g3.114.011726

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