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Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction
BACKGROUND: The Brain Reward Cascade (BRC) is an interaction of neurotransmitters and their respective genes to control the amount of dopamine released within the brain. Any variations within this pathway, whether genetic or environmental (epigenetic), may result in addictive behaviors or RDS, which...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455960/ https://www.ncbi.nlm.nih.gov/pubmed/26052557 http://dx.doi.org/10.17756/jrds.2015-009 |
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author | Blum, Kenneth Badgaiyan, Rajendra D. Agan, Gozde Fratantonio, James Simpatico, Thomas Febo, Marcelo Haberstick, Brett C. Smolen, Andrew Gold, Mark S. |
author_facet | Blum, Kenneth Badgaiyan, Rajendra D. Agan, Gozde Fratantonio, James Simpatico, Thomas Febo, Marcelo Haberstick, Brett C. Smolen, Andrew Gold, Mark S. |
author_sort | Blum, Kenneth |
collection | PubMed |
description | BACKGROUND: The Brain Reward Cascade (BRC) is an interaction of neurotransmitters and their respective genes to control the amount of dopamine released within the brain. Any variations within this pathway, whether genetic or environmental (epigenetic), may result in addictive behaviors or RDS, which was coined to define addictive behaviors and their genetic components. METHODS: To carry out this review we searched a number of important databases including: Filtered: Cochrane Systematic reviews; DARE; Pubmed Central Clinical Quaries; National Guideline Clearinghouse and unfiltered resources: PsychINFO; ACP PIER; PsychSage; Pubmed/Medline. The major search terms included: dopamine agonist therapy for Addiction; dopamine agonist therapy for Reward dependence; dopamine antagonistic therapy for addiction; dopamine antagonistic therapy for reward dependence and neurogenetics of RDS. RESULTS: While there are many studies claiming a genetic association with RDS behavior, not all are scientifically accurate. CONCLUSION: Albeit our bias, this Clinical Pearl discusses the facts and fictions behind molecular genetic testing in RDS and the significance behind the development of the Genetic Addiction Risk Score (GARS(PREDX)™), the first test to accurately predict one’s genetic risk for RDS. |
format | Online Article Text |
id | pubmed-4455960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-44559602015-06-04 Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction Blum, Kenneth Badgaiyan, Rajendra D. Agan, Gozde Fratantonio, James Simpatico, Thomas Febo, Marcelo Haberstick, Brett C. Smolen, Andrew Gold, Mark S. J Reward Defic Syndr Article BACKGROUND: The Brain Reward Cascade (BRC) is an interaction of neurotransmitters and their respective genes to control the amount of dopamine released within the brain. Any variations within this pathway, whether genetic or environmental (epigenetic), may result in addictive behaviors or RDS, which was coined to define addictive behaviors and their genetic components. METHODS: To carry out this review we searched a number of important databases including: Filtered: Cochrane Systematic reviews; DARE; Pubmed Central Clinical Quaries; National Guideline Clearinghouse and unfiltered resources: PsychINFO; ACP PIER; PsychSage; Pubmed/Medline. The major search terms included: dopamine agonist therapy for Addiction; dopamine agonist therapy for Reward dependence; dopamine antagonistic therapy for addiction; dopamine antagonistic therapy for reward dependence and neurogenetics of RDS. RESULTS: While there are many studies claiming a genetic association with RDS behavior, not all are scientifically accurate. CONCLUSION: Albeit our bias, this Clinical Pearl discusses the facts and fictions behind molecular genetic testing in RDS and the significance behind the development of the Genetic Addiction Risk Score (GARS(PREDX)™), the first test to accurately predict one’s genetic risk for RDS. 2015-03-19 2015 /pmc/articles/PMC4455960/ /pubmed/26052557 http://dx.doi.org/10.17756/jrds.2015-009 Text en Copyright: © Blum et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY) (http://creativecommons.org/licenses/by/4.0/) which permits commercial use, including reproduction, adaptation, and distribution of the article provided the original author and source are credited. |
spellingShingle | Article Blum, Kenneth Badgaiyan, Rajendra D. Agan, Gozde Fratantonio, James Simpatico, Thomas Febo, Marcelo Haberstick, Brett C. Smolen, Andrew Gold, Mark S. Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction |
title | Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction |
title_full | Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction |
title_fullStr | Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction |
title_full_unstemmed | Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction |
title_short | Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction |
title_sort | molecular genetic testing in reward deficiency syndrome (rds): facts and fiction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455960/ https://www.ncbi.nlm.nih.gov/pubmed/26052557 http://dx.doi.org/10.17756/jrds.2015-009 |
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