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Pneumococcal IgA1 Protease Subverts Specific Protection By Human IgA1

Bacterial IgA1 proteases may sabotage the protective effects of IgA. In vitro, both exogenous and endogenously-produced IgA1 protease inhibited phagocytic killing of Streptococcus pneumoniae by capsule-specific IgA1 human monoclonal antibodies (hMAb's), but not IgA2. These IgA1 proteases cleave...

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Detalles Bibliográficos
Autores principales:	Janoff, Edward N., Rubins, Jeffrey B., Fasching, Claudine, Charboneau, Darlene, Rahkola, Jeremy T., Plaut, Andrew G., Weiser, Jeffrey N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456019/ https://www.ncbi.nlm.nih.gov/pubmed/23820749 http://dx.doi.org/10.1038/mi.2013.41

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