Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

The human APOBEC3G (A3G) DNA cytosine deaminase restricts and hypermutates DNA-based parasites including HIV-1. The viral infectivity factor (Vif) prevents restriction by triggering A3G degradation. While the structure of the A3G catalytic domain is known, the structure of the N-terminal Vif-binding...

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Detalles Bibliográficos
Autores principales: Kouno, Takahide, Luengas, Elizabeth M., Shigematsu, Megumi, Shandilya, Shivender M.D., Zhang, JingYing, Chen, Luan, Hara, Mayuko, Schiffer, Celia A., Harris, Reuben S., Matsuo, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456288/
https://www.ncbi.nlm.nih.gov/pubmed/25984970
http://dx.doi.org/10.1038/nsmb.3033

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